phenamil [Ligand Id: 4281] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL211502 (Phenamil)
  • ENaC α/Amiloride-sensitive sodium channel alpha-subunit in Human [ChEMBL: CHEMBL1791] [GtoPdb: 738] [UniProtKB: P37088]
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  • TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ENaC α/Amiloride-sensitive sodium channel alpha-subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1791] [GtoPdb: 738] [UniProtKB: P37088]
ChEMBL Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay B 6.4 pIC50 401 nM IC50 J. Med. Chem. (2006) 49: 4098-4115 [PMID:16821771]
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
GtoPdb - - 6.9 pIC50 140 nM IC50

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]