SYM2081 [Ligand Id: 4317] activity data from GtoPdb

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  • GluK1 in Human [GtoPdb: 450] [UniProtKB: P39086]
  • GluK1 in Rat [GtoPdb: 450] [UniProtKB: P22756]
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  • GluK2 in Human [GtoPdb: 451] [UniProtKB: Q13002]
  • GluK2 in Rat [GtoPdb: 451] [UniProtKB: P42260]
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  • GluK3 in Rat [GtoPdb: 452] [UniProtKB: P42264]
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  • Excitatory amino acid transporter 2 in Human [GtoPdb: 869] [UniProtKB: P43004]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluK1 in Human [GtoPdb: 450] [UniProtKB: P39086]
GtoPdb - - 8.52 pKi 3 nM Ki J. Med. Chem. (2000) 43: 1958-68 [PMID:10821708]
GluK1 in Rat [GtoPdb: 450] [UniProtKB: P22756]
GtoPdb - - 9.18 pKi 0.66 nM Ki J. Med. Chem. (2008) 51: 4093-103 [PMID:18578478]
GluK2 in Human [GtoPdb: 451] [UniProtKB: Q13002]
GtoPdb - - 8 pKi 10 nM Ki J. Med. Chem. (2000) 43: 1958-68 [PMID:10821708]
GluK2 in Rat [GtoPdb: 451] [UniProtKB: P42260]
GtoPdb Measuring displacement of [3H]kainate binding to recombinant rGluR6 receptors. - 8.01 pKi 9.8 nM Ki J. Pharmacol. Exp. Ther. (1997) 280: 422-7 [PMID:8996224];
J. Med. Chem. (2008) 51: 4093-103 [PMID:18578478]
GtoPdb - - 7.72 pIC50 19 nM IC50 J. Pharmacol. Exp. Ther. (1997) 280: 422-7 [PMID:8996224]
GluK3 in Rat [GtoPdb: 452] [UniProtKB: P42264]
GtoPdb - - 8.24 pKi 5.69 nM Ki J. Med. Chem. (2008) 51: 4093-103 [PMID:18578478]
Excitatory amino acid transporter 2 in Human [GtoPdb: 869] [UniProtKB: P43004]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.