toremifene [Ligand Id: 4325] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1655 (Acapodene, Chlortamoxifen, Farestone, GTX-006, J33.157K, Toremifene, Toremiphene) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Envelope glycoprotein in Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105829] [UniProtKB: Q05320] | ||||||||
| ChEMBL | Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assay | B | 4.8 | pKd | 16000 | nM | Kd | J Med Chem (2018) 61: 724-733 [PMID:29272110] |
| ChEMBL | Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain T42A mutant tagged with 6xHis/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells at pH 5.2 by SYPRO orange dye-based fluorescence assay | B | 4.8 | pKd | 16000 | nM | Kd | J Med Chem (2018) 61: 4938-4945 [PMID:29741894] |
| ChEMBL | Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry | B | 7.2 | pEC50 | 62.8 | nM | EC50 | J Med Chem (2020) 63: 7211-7225 [PMID:32490678] |
| ChEMBL | Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entry | B | 7.2 | pEC50 | 62.8 | nM | EC50 | J Med Chem (2020) 63: 7211-7225 [PMID:32490678] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting | B | 5.38 | pKi | 4125 | nM | Ki | J Med Chem (2012) 55: 5704-5719 [PMID:22537153] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
