toremifene [Ligand Id: 4325] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1655 (Toremifene, J33.157K, GTX-006)
  • Envelope glycoprotein in Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) [ChEMBL: CHEMBL4105829] [UniProtKB: Q05320]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Envelope glycoprotein in Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105829] [UniProtKB: Q05320]
ChEMBL Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assay B 4.8 pKd 16000 nM Kd J Med Chem (2018) 61: 724-733 [PMID:29272110]
ChEMBL Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain T42A mutant tagged with 6xHis/foldon trimerization sequence from the bacteriophage T4 fibritin at C terminal expressed in HEK293T cells at pH 5.2 by SYPRO orange dye-based fluorescence assay B 4.8 pKd 16000 nM Kd J Med Chem (2018) 61: 4938-4945 [PMID:29741894]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting B 5.38 pKi 4125 nM Ki J. Med. Chem. (2012) 55: 5704-5719 [PMID:22537153]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]