ChEMBL ligand: CHEMBL585 (Dyrenium, Dytac, NSC-639359, NSC-77625, SK-8542, SK&F 8542, SK&F-8542, Triamterene)
Caspase 1/Caspase-1 in Human [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] There should be some charts here, you may need to enable JavaScript!
cathepsin G/Cathepsin G in Human [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311] There should be some charts here, you may need to enable JavaScript!
CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Pteridine reductase 1 in Leishmania major [ChEMBL: CHEMBL6194] [UniProtKB: Q01782] There should be some charts here, you may need to enable JavaScript!
ENaCαβγ in Human [GtoPdb: 742] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL	DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC)	B	5.44	pIC50	3663	nM	IC50	DrugMatrix in vitro pharmacology data
cathepsin G/Cathepsin G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311]
ChEMBL	DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC)	B	5.13	pIC50	7413	nM	IC50	DrugMatrix in vitro pharmacology data
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL	DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	5	pIC50	10000	nM	IC50	DrugMatrix in vitro pharmacology data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	4.02	pIC50	95000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against transgenic Plasmodium falciparum HB3 pDT harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	4.02	pIC50	95000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum AL2 after 72 hrs by SYBR green assay	F	4.09	pIC50	81846	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum AL2 after 72 hrs by SYBR green assay	F	4.09	pIC50	81846	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF10 after 72 hrs by SYBR green assay	F	4.12	pIC50	75051	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF10 after 72 hrs by SYBR green assay	F	4.12	pIC50	75051	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KC5 after 72 hrs by SYBR green assay	F	4.13	pIC50	73540	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KC5 after 72 hrs by SYBR green assay	F	4.13	pIC50	73540	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	4.15	pIC50	70000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum DAN after 72 hrs by SYBR green assay	F	4.16	pIC50	69472	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum DAN after 72 hrs by SYBR green assay	F	4.16	pIC50	69472	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JB12 after 72 hrs by SYBR green assay	F	4.19	pIC50	65106	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JB12 after 72 hrs by SYBR green assay	F	4.19	pIC50	65106	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JH6 after 72 hrs by SYBR green assay	F	4.19	pIC50	64808	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JH6 after 72 hrs by SYBR green assay	F	4.19	pIC50	64808	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum DEV after 72 hrs by SYBR green assay	F	4.22	pIC50	60466	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum DEV after 72 hrs by SYBR green assay	F	4.22	pIC50	60466	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KC2 after 72 hrs by SYBR green assay	F	4.22	pIC50	60436	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KC2 after 72 hrs by SYBR green assay	F	4.22	pIC50	60436	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XD8 after 72 hrs by SYBR green assay	F	4.22	pIC50	59779	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XD8 after 72 hrs by SYBR green assay	F	4.22	pIC50	59779	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XB3 after 72 hrs by SYBR green assay	F	4.24	pIC50	56991	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XB3 after 72 hrs by SYBR green assay	F	4.24	pIC50	56991	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KB8 after 72 hrs by SYBR green assay	F	4.25	pIC50	56298	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum AUD after 72 hrs by SYBR green assay	F	4.27	pIC50	54210	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum AUD after 72 hrs by SYBR green assay	F	4.27	pIC50	54210	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum WC4 after 72 hrs by SYBR green assay	F	4.28	pIC50	52491	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum WC4 after 72 hrs by SYBR green assay	F	4.28	pIC50	52491	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	4.29	pIC50	51711	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum LC12 after 72 hrs by SYBR green assay	F	4.3	pIC50	50137	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum LC12 after 72 hrs by SYBR green assay	F	4.3	pIC50	50137	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JB8 after 72 hrs by SYBR green assay	F	4.31	pIC50	49372	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JB8 after 72 hrs by SYBR green assay	F	4.31	pIC50	49372	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum WE2 after 72 hrs by SYBR green assay	F	4.35	pIC50	44555	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum WE2 after 72 hrs by SYBR green assay	F	4.35	pIC50	44555	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JC9 after 72 hrs by SYBR green assay	F	4.36	pIC50	43663	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JC9 after 72 hrs by SYBR green assay	F	4.36	pIC50	43663	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D2 after 72 hrs by SYBR green assay	F	4.65	pIC50	22168	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D2 after 72 hrs by SYBR green assay	F	4.65	pIC50	22168	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XE7 after 72 hrs by SYBR green assay	F	4.74	pIC50	18063	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XE7 after 72 hrs by SYBR green assay	F	4.74	pIC50	18063	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	4.76	pIC50	17210	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XF12 after 72 hrs by SYBR green assay	F	4.77	pIC50	17071	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XF12 after 72 hrs by SYBR green assay	F	4.77	pIC50	17071	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KH7 after 72 hrs by SYBR green assay	F	4.82	pIC50	15024	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KH7 after 72 hrs by SYBR green assay	F	4.82	pIC50	15024	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NIC after 72 hrs by SYBR green assay	F	4.95	pIC50	11246	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NIC after 72 hrs by SYBR green assay	F	4.95	pIC50	11246	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum TF1 after 72 hrs by SYBR green assay	F	5.05	pIC50	8822	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum TF1 after 72 hrs by SYBR green assay	F	5.05	pIC50	8822	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XG10 after 72 hrs by SYBR green assay	F	5.09	pIC50	8126	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum XG10 after 72 hrs by SYBR green assay	F	5.09	pIC50	8126	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum WF12 after 72 hrs by SYBR green assay	F	5.23	pIC50	5826	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum LA10 after 72 hrs by SYBR green assay	F	5.25	pIC50	5588	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum LA10 after 72 hrs by SYBR green assay	F	5.25	pIC50	5588	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	5.28	pIC50	5300	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KA6 after 72 hrs by SYBR green assay	F	5.28	pIC50	5191	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum KA6 after 72 hrs by SYBR green assay	F	5.28	pIC50	5191	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JF11 after 72 hrs by SYBR green assay	F	5.29	pIC50	5110	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JF11 after 72 hrs by SYBR green assay	F	5.29	pIC50	5110	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JC3 after 72 hrs by SYBR green assay	F	5.37	pIC50	4263	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JC3 after 72 hrs by SYBR green assay	F	5.37	pIC50	4263	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against transgenic Plasmodium falciparum Dd2 pDT harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	5.4	pIC50	4000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum QF5 after 72 hrs by SYBR green assay	F	5.45	pIC50	3540	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum QF5 after 72 hrs by SYBR green assay	F	5.45	pIC50	3540	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JON after 72 hrs by SYBR green assay	F	5.48	pIC50	3294	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum JON after 72 hrs by SYBR green assay	F	5.48	pIC50	3294	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5.6	pIC50	2511.89	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 harboring polymorphic DHFR after 72 hrs by SYBR green assay	F	5.66	pIC50	2200	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5.66	pIC50	2190	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.7	pIC50	1995.26	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	6	pIC50	1000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Pteridine reductase 1 in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6194] [UniProtKB: Q01782]
ChEMBL	Inhibition of Leishmania major recombinant PTR1	B	5.47	pKi	3400	nM	Ki	J Med Chem (2010) 53: 221-229 [PMID:19916554]
ENaCαβγ in Human [GtoPdb: 742]
GtoPdb	-	-	5.3	pIC50	~5000	nM	IC50	Nature (1994) 367: 463-7 [PMID:8107805]; Mol Pharmacol (2003) 64: 848-56 [PMID:14500741]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]