zaleplon [Ligand Id: 4345] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1521 (LJC 10846, ZAL-846, Zaleplon, L-846, SKP-1041, CL-284846, LJC-10846, Sonata, Zaleplon civ, CL 284,846, L846)
  • GABAA receptor α1 subunit/GABAA receptor γ2 subunit/GABAA receptor β2 subunit/GABA-A receptor; alpha-1/beta-2/gamma-2 in Human [ChEMBL: CHEMBL2095172] [GtoPdb: 404414411] [UniProtKB: P14867P18507P47870]
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  • GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α2 subunit/GABA-A receptor; alpha-2/beta-3/gamma-2 in Human [ChEMBL: CHEMBL2094130] [GtoPdb: 414412405] [UniProtKB: P18507P28472P47869]
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  • GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α3 subunit/GABA-A receptor; alpha-3/beta-3/gamma-2 in Human [ChEMBL: CHEMBL2094120] [GtoPdb: 414412406] [UniProtKB: P18507P28472P34903]
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  • GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor γ3 subunit/Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3 in Human [ChEMBL: CHEMBL3885577] [GtoPdb: 412408415] [UniProtKB: P28472P31644Q99928]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GABAA receptor α1 subunit/GABAA receptor γ2 subunit/GABAA receptor β2 subunit/GABA-A receptor; alpha-1/beta-2/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095172] [GtoPdb: 404414411] [UniProtKB: P14867P18507P47870]
ChEMBL Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents B 6.54 pEC50 290 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α2 subunit/GABA-A receptor; alpha-2/beta-3/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094130] [GtoPdb: 414412405] [UniProtKB: P18507P28472P47869]
ChEMBL Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents B 5.79 pEC50 1630 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α3 subunit/GABA-A receptor; alpha-3/beta-3/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094120] [GtoPdb: 414412406] [UniProtKB: P18507P28472P34903]
ChEMBL Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents B 6 pEC50 >1000 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor γ3 subunit/Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885577] [GtoPdb: 412408415] [UniProtKB: P28472P31644Q99928]
ChEMBL Modulation of human GABAA alpha5beta3gamma3 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents B 6 pEC50 >1000 nM EC50 J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]