CXCL12α [Ligand Id: 4358] activity data from GtoPdb

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  • CXCR3 in Human [GtoPdb: 70] [UniProtKB: P49682]
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  • CXCR4 in Human [GtoPdb: 71] [UniProtKB: P61073]
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  • ACKR3 in Human [GtoPdb: 80] [UniProtKB: P25106]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CXCR3 in Human [GtoPdb: 70] [UniProtKB: P49682]
GtoPdb - - 6.4 pKi - - - J. Biol. Chem. (1998) 273: 18288-91 [PMID:9660793]
CXCR4 in Human [GtoPdb: 71] [UniProtKB: P61073]
GtoPdb - - 8.2 pKd - - - J. Immunol. (1998) 160: 877-83 [PMID:9551924];
J. Biol. Chem. (1998) 273: 22279-83 [PMID:9712844]
GtoPdb Measuring CXCL12-induced displacement of CXCR4-bound 125I-CXCL12 from membranes prepared from HEK293T cells expressing human CXCR4. - 9.3 pIC50 0.5 nM IC50 European Journal of Medicinal Chemistry (2018) 162: 631-649
ACKR3 in Human [GtoPdb: 80] [UniProtKB: P25106]
GtoPdb - - 7.9 pEC50 - - - J. Biol. Chem. (2010) 285: 37939-43 [PMID:20956518];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.