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ChEMBL ligand: CHEMBL268697 (HC-3, hemicholinium-3) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by picogreen-microfluorimetric assay | F | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorimetric assay | F | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399] |
CHT in Human [GtoPdb: 914] [UniProtKB: Q9GZV3] | ||||||||
GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | Neurochem Res (2003) 28: 483-8 [PMID:12675135] |
Choline transporter-like 1 in Human [GtoPdb: 1204] [UniProtKB: Q8WWI5] | ||||||||
GtoPdb | - | - | 4.5 | pKi | 31000 | nM | Ki |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]