[3H]BSP [Ligand Id: 4505] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL453904 (Bromosulfalein, Sodium Bromsulphalein, Bromthalein, Sulphobromophthalein, Sulfobromophthalein sodium, Hepatosulfalein, Sulfobromophthalein, Sulfobromphthalein sodium)
  • Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
  • This target only has 0 pki data point
  • 0
1 CHEMBL453904_lig_chart_1 Bile acid transporter Human
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  • ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
  • 5.6
2 CHEMBL453904_lig_chart_2 Canalicular multispecific organic anion transporter 1 Rat
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  • Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
  • This target only has 1 pki data point
  • 5.7
3 CHEMBL453904_lig_chart_3 Solute carrier organic anion transporter family member 1A1 Rat
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  • Solute carrier organic anion transporter family member 1A3 in Rat [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
  • This target only has 1 pki data point
  • 4.68
4 CHEMBL453904_lig_chart_4 Solute carrier organic anion transporter family member 1A3 Rat
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  • OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
  • This target only has 1 pki data point
  • 7.36
5 CHEMBL453904_lig_chart_5 Solute carrier organic anion transporter family member 1B1 Human
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  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
  • This target only has 1 pki data point
  • 5.24
6 CHEMBL453904_lig_chart_6 Solute carrier organic anion transporter family member 2A1 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells F 5.14 pIC50 7300 nM IC50 J. Pharmacol. Exp. Ther. (1999) 291: 1204-1209 [PMID:10565843]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat F 5.54 pKi 2870 nM Ki Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649]
ChEMBL TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat F 5.66 pKi 2180 nM Ki Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells F 5.7 pKi 1980 nM Ki Hepatology (1998) 28: 1341-1346 [PMID:9794920]
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells F 4.68 pKi 21000 nM Ki J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408]
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake in OATP-C-expressing HEK293 cells F 7.36 pKi 44 nM Ki Am. J. Physiol. Gastrointest. Liver Physiol. (2000) 278: G156-G164 [PMID:10644574]
ChEMBL TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells F 7.3 pIC50 50 nM IC50 Naunyn Schmiedebergs Arch. Pharmacol. (2003) 368: 415-420 [PMID:14530907]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
ChEMBL TP_TRANSPORTER: inhibition of PGF2alpha uptake in PGT-expressing HeLa cells F 5.24 pKi 5800 nM Ki Science (1995) 268: 866-869 [PMID:7754369]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]