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ChEMBL ligand: CHEMBL453904 (Bromosulfalein, Bromsulphthalein, Bromthalein, Bsp sodium, Hepartest, Hepatestabrome, Hepatosulfalein, Sodium Bromsulphalein, Sodium bromsulphthalein, Sulfobromophthalein, Sulfobromophthalein sodium, Sulfobromopthalein sodium, Sulfobromphthalein sodium, Sulphobromophthalein) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells | F | 5.14 | pIC50 | 7300 | nM | IC50 | J. Pharmacol. Exp. Ther. (1999) 291: 1204-1209 [PMID:10565843] |
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat | F | 5.54 | pKi | 2870 | nM | Ki | Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649] |
ChEMBL | TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat | F | 5.66 | pKi | 2180 | nM | Ki | Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649] |
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells | F | 5.7 | pKi | 1980 | nM | Ki | Hepatology (1998) 28: 1341-1346 [PMID:9794920] |
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | F | 4.68 | pKi | 21000 | nM | Ki | J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408] |
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake in OATP-C-expressing HEK293 cells | F | 7.36 | pKi | 44 | nM | Ki | Am. J. Physiol. Gastrointest. Liver Physiol. (2000) 278: G156-G164 [PMID:10644574] |
ChEMBL | TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells | F | 7.3 | pIC50 | 50 | nM | IC50 | Naunyn Schmiedebergs Arch. Pharmacol. (2003) 368: 415-420 [PMID:14530907] |
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of PGF2alpha uptake in PGT-expressing HeLa cells | F | 5.24 | pKi | 5800 | nM | Ki | Science (1995) 268: 866-869 [PMID:7754369] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]