[3H]taurocholic acid [Ligand Id: 4546] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL224867 (Cholaic acid, Cholic acid taurine conjugate, N-Choloyltaurine, Taurocholic acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells | F | 5.28 | pIC50 | 5300 | nM | IC50 | J Pharmacol Exp Ther (1999) 291: 1204-1209 [PMID:10565843] |
| Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4847] [GtoPdb: 959] [UniProtKB: P26435] | ||||||||
| ChEMBL | Inhibition of [3H]taurocholate uptake in rat hepatocytes | F | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4179-4183 [PMID:15261266] |
| GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
| ChEMBL | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | F | 5.31 | pEC50 | 4950 | nM | EC50 | J Med Chem (2008) 51: 1831-1841 [PMID:18307294] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells | F | 4.38 | pKi | 41500 | nM | Ki | Am J Physiol (1998) 274: G157-G169 [PMID:9458785] |
| Multidrug resistance associated protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073669] [UniProtKB: Q96QA9] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.4 uM) in membrane vesicles from MRP3-expressing HEK cells | F | 4.4 | pIC50 | 40000 | nM | IC50 | Biochemistry (2003) 42: 9989-10000 [PMID:12924948] |
| Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells | F | 4.49 | pKi | 32000 | nM | Ki | Hepatology (1998) 28: 1341-1346 [PMID:9794920] |
| ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells | F | 4.97 | pKi | 10800 | nM | Ki | J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557] |
| Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp2-expressing LLC-PK1 cells | F | 4.4 | pKi | 39400 | nM | Ki | J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
