ChEMBL ligand: CHEMBL224867 (Cholaic acid, Cholic acid taurine conjugate, N-Choloyltaurine, Taurocholic acid)
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Rat [ChEMBL: CHEMBL4847] [GtoPdb: 959] [UniProtKB: P26435] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] There should be some charts here, you may need to enable JavaScript!
Multidrug resistance associated protein in Human [ChEMBL: CHEMBL2073669] [UniProtKB: Q96QA9] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells	F	5.28	pIC50	5300	nM	IC50	J Pharmacol Exp Ther (1999) 291: 1204-1209 [PMID:10565843]
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4847] [GtoPdb: 959] [UniProtKB: P26435]
ChEMBL	Inhibition of [3H]taurocholate uptake in rat hepatocytes	F	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4179-4183 [PMID:15261266]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	5.31	pEC50	4950	nM	EC50	J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells	F	4.38	pKi	41500	nM	Ki	Am J Physiol (1998) 274: G157-G169 [PMID:9458785]
Multidrug resistance associated protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073669] [UniProtKB: Q96QA9]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.4 uM) in membrane vesicles from MRP3-expressing HEK cells	F	4.4	pIC50	40000	nM	IC50	Biochemistry (2003) 42: 9989-10000 [PMID:12924948]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells	F	4.49	pKi	32000	nM	Ki	Hepatology (1998) 28: 1341-1346 [PMID:9794920]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells	F	4.97	pKi	10800	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp2-expressing LLC-PK1 cells	F	4.4	pKi	39400	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]