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ChEMBL ligand: CHEMBL224867 (Cholaic acid, Cholic acid taurine conjugate, N-Choloyltaurine, Taurocholic acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells | F | 5.28 | pIC50 | 5300 | nM | IC50 | J. Pharmacol. Exp. Ther. (1999) 291: 1204-1209 [PMID:10565843] |
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4847] [GtoPdb: 959] [UniProtKB: P26435] | ||||||||
ChEMBL | Inhibition of [3H]taurocholate uptake in rat hepatocytes | F | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2004) 14: 4179-4183 [PMID:15261266] |
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
ChEMBL | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | F | 5.31 | pEC50 | 4950 | nM | EC50 | J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294] |
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells | F | 4.38 | pKi | 41500 | nM | Ki | Am. J. Physiol. (1998) 274: G157-G169 [PMID:9458785] |
Multidrug resistance associated protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073669] [UniProtKB: Q96QA9] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.4 uM) in membrane vesicles from MRP3-expressing HEK cells | F | 4.4 | pIC50 | 40000 | nM | IC50 | Biochemistry (2003) 42: 9989-10000 [PMID:12924948] |
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells | F | 4.49 | pKi | 32000 | nM | Ki | Hepatology (1998) 28: 1341-1346 [PMID:9794920] |
ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells | F | 4.97 | pKi | 10800 | nM | Ki | J. Pharmacol. Exp. Ther. (2001) 298: 316-322 [PMID:11408557] |
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp2-expressing LLC-PK1 cells | F | 4.4 | pKi | 39400 | nM | Ki | J. Pharmacol. Exp. Ther. (2001) 298: 316-322 [PMID:11408557] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]