hypoxanthine [Ligand Id: 4555] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1427 (Hypoxanthine)
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  • Purine nucleoside phosphorylase in Bovine [ChEMBL: CHEMBL2935] [UniProtKB: P55859]
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  • purine nucleoside phosphorylase/Purine-nucleoside phosphorylase in Rat [ChEMBL: CHEMBL2395] [GtoPdb: 2841] [UniProtKB: P85973]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 F 5.38 pIC50 4200 nM IC50 J. Med. Chem. (2006) 49: 7479-7486 [PMID:17149876]
Purine nucleoside phosphorylase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2935] [UniProtKB: P55859]
ChEMBL Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis B 5.9 pKd 1250 nM Kd Bioorg. Med. Chem. (2012) 20: 6758-6769 [PMID:23040896]
ChEMBL Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry B 6.17 pKd 680 nM Kd Bioorg. Med. Chem. (2012) 20: 6758-6769 [PMID:23040896]
purine nucleoside phosphorylase/Purine-nucleoside phosphorylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2395] [GtoPdb: 2841] [UniProtKB: P85973]
ChEMBL Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) B 4.77 pKi 17000 nM Ki J. Med. Chem. (1994) 37: 2477-2480 [PMID:8057293]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]