[3H]folic acid [Ligand Id: 4562] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1622 (Natur Flow, Bio Science, Folacin, Vitamin Bc, Vitamin M, NSC-3073, Folicet, Preconceive, Roche, Folic Acid, Folsan, Lexpec, Pteroylglutamic Acid, Folicare, Folvite, B03BB01)
  • Dihydrofolate reductase in Escherichia coli [ChEMBL: CHEMBL5441] [UniProtKB: B0BL08]
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  • Solute carrier organic anion transporter family member 1A3 in Rat [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
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  • thymidylate synthetase/Thymidylate synthase in Human [ChEMBL: CHEMBL1952] [GtoPdb: 2642] [UniProtKB: P04818]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5441] [UniProtKB: B0BL08]
ChEMBL Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 B 5.32 pKd 4800 nM Kd J. Med. Chem. (1988) 31: 129-137 [PMID:3275776]
ChEMBL Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 B 5.36 pKd 4400 nM Kd J. Med. Chem. (1988) 31: 129-137 [PMID:3275776]
ChEMBL Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 B 6.09 pKd 810 nM Kd J. Med. Chem. (1988) 31: 129-137 [PMID:3275776]
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells F 4.85 pKi 14100 nM Ki J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408]
thymidylate synthetase/Thymidylate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1952] [GtoPdb: 2642] [UniProtKB: P04818]
ChEMBL Inhibitory constant of thymidylate synthase was determined in human AML cells B 4.4 pKi 40000 nM Ki J. Med. Chem. (1987) 30: 675-678 [PMID:3470522]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]