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ChEMBL ligand: CHEMBL1622 (Natur Flow, Bio Science, Folacin, Vitamin Bc, Vitamin M, NSC-3073, Folicet, Preconceive, Roche, Folic Acid, Folsan, Lexpec, Pteroylglutamic Acid, Folicare, Folvite, B03BB01) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5441] [UniProtKB: B0BL08] | ||||||||
ChEMBL | Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.32 | pKd | 4800 | nM | Kd | J. Med. Chem. (1988) 31: 129-137 [PMID:3275776] |
ChEMBL | Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.36 | pKd | 4400 | nM | Kd | J. Med. Chem. (1988) 31: 129-137 [PMID:3275776] |
ChEMBL | Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 6.09 | pKd | 810 | nM | Kd | J. Med. Chem. (1988) 31: 129-137 [PMID:3275776] |
Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | F | 4.85 | pKi | 14100 | nM | Ki | J. Pharmacol. Exp. Ther. (2000) 293: 1034-1039 [PMID:10869408] |
thymidylate synthetase/Thymidylate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1952] [GtoPdb: 2642] [UniProtKB: P04818] | ||||||||
ChEMBL | Inhibitory constant of thymidylate synthase was determined in human AML cells | B | 4.4 | pKi | 40000 | nM | Ki | J. Med. Chem. (1987) 30: 675-678 [PMID:3470522] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]