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ChEMBL ligand: CHEMBL431733 (Cf102, CF-102, CF102, Chloro-ib-meca, CI-IB-MECA, CL-IB-MECA, Namodenoson) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Displacement of [3H]R-PLA from human adenosine A1 receptor expressed in CHO cells after 60 mins by liquid scintillation analyzer | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2017) 60: 3422-3437 [PMID:28380296] |
ChEMBL | Binding affinity for human Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2003) 46: 3775-3777 [PMID:12930138] |
ChEMBL | Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cells | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2004) 47: 4766-4773 [PMID:15341491] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane after 180 mins | B | 6.05 | pKi | 890 | nM | Ki | Eur J Med Chem (2013) 69: 331-337 [PMID:24077183] |
ChEMBL | Displacement of [3H]DPDPX from human adenosine A1 receptor expressed in CHO cells | B | 6.05 | pKi | 890 | nM | Ki | J Med Chem (2008) 51: 1764-1770 [PMID:18269230] |
ChEMBL | Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membrane | B | 6.05 | pKi | 890 | nM | Ki | J Med Chem (2012) 55: 1490-1499 [PMID:22257095] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | B | 6.05 | pKi | 890 | nM | Ki | J Med Chem (2007) 50: 5676-5684 [PMID:17927167] |
ChEMBL | Displacement of [3H]CHA binding to Adenosine A1 receptor expressed in CHO cells | B | 6.08 | pKi | 823 | nM | Ki | J Med Chem (2004) 47: 5535-5540 [PMID:15481989] |
ChEMBL | Displacement of [3H]CCPA from human adenosine A1 receptor in CHO cells | B | 6.65 | pKi | 222 | nM | Ki | J Med Chem (2007) 50: 3159-3162 [PMID:17555308] |
ChEMBL | Displacement of [3H]CCPA from human A1 receptor expressed in CHO cell membranes after 60 mins by gamma counting method | B | 6.65 | pKi | 222 | nM | Ki | J Med Chem (2017) 60: 7459-7475 [PMID:28799755] |
ChEMBL | Displacement of [3H]R-PIA from human adenosine A1 receptor expressed in CHO cells | B | 6.65 | pKi | 222 | nM | Ki | Bioorg Med Chem (2009) 17: 8003-8011 [PMID:19879151] |
ChEMBL | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | B | 6.65 | pKi | 222 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1612-1616 [PMID:18255292] |
ChEMBL | Binding affinity towards recombinant human Adenosine A1 receptor was determined using [3H]R-PIA (2.0 nM) as radioligand | B | 6.65 | pKi | 222 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4851-4854 [PMID:15341938] |
ChEMBL | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | B | 6.65 | pKi | 222 | nM | Ki | J Med Chem (2008) 51: 6609-6613 [PMID:18811138] |
ChEMBL | Displacement of [3H]CCPA form human adenosine A1 receptor expressed in CHO cells | B | 6.65 | pKi | 222 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cell membranes after 3 hrs by micro beta scintillation counting method | B | 6.66 | pKi | 220 | nM | Ki | Eur J Med Chem (2018) 157: 837-851 [PMID:30144700] |
ChEMBL | Inhibition of [3H]R-PIA binding to human Adenosine A1 receptor expressed in CHO cells | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of radioligand from human adenosine A1 receptor expressed in CHO cells | B | 6.66 | pKi | 220 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]NECA from human recombinant adenosine A1 receptor expressed in CHO cells by liquid scintillation counting | B | 6.66 | pKi | 220 | nM | Ki | Bioorg Med Chem (2009) 17: 3733-3738 [PMID:19375920] |
ChEMBL | Displacement of [3H]N6-phenylisopropyladenosine from recombinant human A1AR expressed in CHO cell membranes after 60 mins by liquid scintillation counting method | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (2016) 59: 11006-11026 [PMID:27933810] |
GtoPdb | - | - | 6.66 | pKi | 220 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
ChEMBL | Binding affinity using [125I]ABA against human Adenosine A1 receptor | B | 7 | pKi | 99 | nM | Ki | J Med Chem (2003) 46: 353-355 [PMID:12540233] |
ChEMBL | Displacement of [125I]ABA from human adenosine A1 receptor expressed in HEK cells | B | 8.28 | pKi | 5.26 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2416-2418 [PMID:16487705] |
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
ChEMBL | Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes | B | 6.05 | pKi | 890 | nM | Ki | J Med Chem (2005) 48: 1550-1562 [PMID:15743197] |
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] | ||||||||
ChEMBL | Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A1 receptor expressed in HEK293 cells | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
GtoPdb | - | - | 7.46 | pKi | 35 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Binding affinity for adenosine A1 receptor as displacement of [3H]R-PIA from rat brain membranes at 10e-4 M | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (1998) 41: 3186-3201 [PMID:9703464] |
ChEMBL | Binding affinity for rat Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (2003) 46: 3775-3777 [PMID:12930138] |
ChEMBL | Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (1994) 37: 3614-3621 [PMID:7932588] |
ChEMBL | Displacement of radioligand from rat adenosine A1 receptor | B | 6.09 | pKi | 820 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
GtoPdb | - | - | 6.55 | pKi | 280 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain | B | 7.27 | pKi | 54 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 1767-1770 [PMID:9873431] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Inhibition of [3H]-CGS- 21680 binding to human Adenosine A2A receptor expressed in CHO cells | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2a receptor expressed in HEK293 cells by liquid scintillation counting | B | 5.27 | pKi | 5400 | nM | Ki | Bioorg Med Chem (2009) 17: 3733-3738 [PMID:19375920] |
ChEMBL | Displacement of [3 H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from recombinant human adenosine receptor A2A expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (2016) 59: 11006-11026 [PMID:27933810] |
ChEMBL | Displacement of radioligand from human adenosine A2A receptor expressed in HEK293 cells | B | 5.27 | pKi | 5400 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
GtoPdb | - | - | 5.27 | pKi | 5360 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
ChEMBL | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation analyzer | B | 5.27 | pKi | 5370 | nM | Ki | J Med Chem (2017) 60: 3422-3437 [PMID:28380296] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cell membranes after 3 hrs by micro beta scintillation counting method | B | 5.27 | pKi | 5360 | nM | Ki | Eur J Med Chem (2018) 157: 837-851 [PMID:30144700] |
ChEMBL | Binding affinity towards recombinant human Adenosine A2a receptor was determined using [3H]CGS-21680 (10 nM) as radioligand | B | 5.27 | pKi | 5360 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4851-4854 [PMID:15341938] |
ChEMBL | Displacement of [3H]CGS-21680 from recombinant human adenosine A2a receptor expressed in HEK cells | B | 5.27 | pKi | 5360 | nM | Ki | J Med Chem (2004) 47: 4766-4773 [PMID:15341491] |
ChEMBL | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells | B | 5.27 | pKi | 5360 | nM | Ki | J Med Chem (2007) 50: 3159-3162 [PMID:17555308] |
ChEMBL | Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells | B | 5.27 | pKi | 5360 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1612-1616 [PMID:18255292] |
ChEMBL | Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in HEK293 cells | B | 5.27 | pKi | 5360 | nM | Ki | J Med Chem (2008) 51: 6609-6613 [PMID:18811138] |
ChEMBL | Displacement of [3H]R-PIA form human adenosine A2A receptor expressed in HEK cells | B | 5.27 | pKi | 5360 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells | B | 5.27 | pKi | 5360 | nM | Ki | Bioorg Med Chem (2009) 17: 8003-8011 [PMID:19879151] |
ChEMBL | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis | B | 5.27 | pKi | 5360 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Displacement of [3H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cell membranes after 60 mins by gamma counting method | B | 5.27 | pKi | 5360 | nM | Ki | J Med Chem (2017) 60: 7459-7475 [PMID:28799755] |
ChEMBL | Binding affinity for human adenosine A2A receptor in CHO cells using [3H]CGS-21680 | B | 5.27 | pKi | 5360 | nM | Ki | J Med Chem (2003) 46: 3775-3777 [PMID:12930138] |
ChEMBL | Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346 | B | 5.43 | pKi | 3720 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Displacement of [3H]CGS-21680 binding to Adenosine A2 receptor expressed in CHO cells | B | 6.35 | pKi | 448 | nM | Ki | J Med Chem (2004) 47: 5535-5540 [PMID:15481989] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | B | 6.4 | pKi | 401 | nM | Ki | J Med Chem (2007) 50: 5676-5684 [PMID:17927167] |
ChEMBL | Displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes | B | 6.4 | pKi | 401 | nM | Ki | J Med Chem (2005) 48: 1550-1562 [PMID:15743197] |
ChEMBL | Displacement of [3H]NECA from human A2A adenosine receptor expressed in CHO cell membrane | B | 6.4 | pKi | 401 | nM | Ki | J Med Chem (2012) 55: 1490-1499 [PMID:22257095] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cell membrane after 90 mins | B | 6.4 | pKi | 401 | nM | Ki | Eur J Med Chem (2013) 69: 331-337 [PMID:24077183] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | B | 6.4 | pKi | 401 | nM | Ki | J Med Chem (2008) 51: 1764-1770 [PMID:18269230] |
A2A receptor/Adenosine A2a receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2115] [GtoPdb: 19] [UniProtKB: Q60613] | ||||||||
GtoPdb | - | - | 5 | pKi | ~10000 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Displacement of [3H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from mouse recombinant adenosine A2A receptor expressed in HEK293 cells | B | 5 | pKi | 10000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
ChEMBL | Binding affinity for adenosine A2A receptor as displacement of [3H]-CGS- 21680 from rat striatal membranes at 10e-4 M | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (1998) 41: 3186-3201 [PMID:9703464] |
ChEMBL | Binding affinity for rat adenosine A2A receptor of CHO cells using [3H]CGS-21680 | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (2003) 46: 3775-3777 [PMID:12930138] |
ChEMBL | Tested for the binding affinity of A2a receptor by displacing the [3H]-CGS- 21680 in rat striatal membranes | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (1994) 37: 3614-3621 [PMID:7932588] |
ChEMBL | Displacement of radioligand from rat adenosine A2A receptor | B | 6.33 | pKi | 470 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]CGS21680 from rat adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
GtoPdb | - | - | 6.33 | pKi | 470 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 1767-1770 [PMID:9873431] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay | F | 5 | pKi | >10000 | nM | Ki | Eur J Med Chem (2018) 157: 837-851 [PMID:30144700] |
A2B receptor/Adenosine A2b receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2237] [GtoPdb: 20] [UniProtKB: Q60614] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Activation of mouse adenosine A2B receptor | B | 5 | pEC50 | >=10000 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Binding affinity to human adenosine A3 receptor measured by radioligand binding assay | B | 5.85 | pKi | 1400 | nM | Ki | ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351] |
ChEMBL | Binding affinity towards human adenosine A3 receptor | B | 7 | pKi | >=99 | nM | Ki | Eur J Med Chem (2022) 231: 114103-114103 [PMID:35152062] |
ChEMBL | Binding affinity towards Adenosine A3 receptor (H95A mutant receptor) | B | 7.22 | pKi | 60 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Competitive binding affinity to human adenosine A3 receptor expressed in CHO cells after 90 mins by flow cytometric analysis in presence of MRS5449 | B | 7.56 | pKi | 27.7 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Binding affinity at Mutant (H272E) human adenosine A3 receptor expressed in COS-7 cells | B | 7.7 | pKi | 20.1 | nM | Ki | J Med Chem (2001) 44: 4125-4136 [PMID:11708915] |
ChEMBL | Binding affinity using [125I]ABA against human Adenosine A3 receptor | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (2003) 46: 353-355 [PMID:12540233] |
ChEMBL | Binding affinity for CHO cell membrane expressing human A3AR with GTPgammaS using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Binding affinity at wild-type Adenosine A3 receptor expressed in COS-7 cells | B | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2001) 44: 4125-4136 [PMID:11708915] |
ChEMBL | Binding affinity towards Adenosine A3 receptor (W243 mutant) receptor | B | 8.54 | pKi | 2.9 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Binding affinity towards human Adenosine A3 receptor wild type | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
ChEMBL | Binding affinity for CHO cell membrane expressing human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
ChEMBL | Displacement of [3H]CGS21680 form human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Binding affinity towards human Adenosine A3 receptor stably transfected in CHO cells was determined using [125I]I-AB-MECA (1.0 nM) as radioligand | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4851-4854 [PMID:15341938] |
ChEMBL | Displacement of [125I]-AB MECA from recombinant human adenosine A3 receptor expressed in HEK cells | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2004) 47: 4766-4773 [PMID:15341491] |
ChEMBL | Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2007) 50: 3159-3162 [PMID:17555308] |
ChEMBL | Displacement of [3H]ABMECA from human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1612-1616 [PMID:18255292] |
ChEMBL | Displacement of radioligand from human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2008) 51: 6609-6613 [PMID:18811138] |
ChEMBL | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells by liquid scintillation counting | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem (2009) 17: 3733-3738 [PMID:19375920] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem (2009) 17: 8003-8011 [PMID:19879151] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells after 90 mins by gamma counting analysis | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Binding affinity to Adenosine receptor A3 (unknown origin) | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2016) 59: 810-840 [PMID:26390077] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting analysis | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2017) 60: 3422-3437 [PMID:28380296] |
ChEMBL | Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cell membranes after 60 mins by gamma counting method | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2017) 60: 7459-7475 [PMID:28799755] |
ChEMBL | Displacement of [3H]HEMADO from human adenosine A3 receptor expressed in CHO cell membranes after 3 hrs by micro beta scintillation counting method | B | 8.85 | pKi | 1.4 | nM | Ki | Eur J Med Chem (2018) 157: 837-851 [PMID:30144700] |
ChEMBL | Binding affinity to human A3AR assessed as inhibitor constant | B | 8.85 | pKi | 1.4 | nM | Ki | ACS Med Chem Lett (2020) 11: 1935-1941 [PMID:33062176] |
ChEMBL | Affinity for human Adenosine A3 receptor expressed in CHO cell | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2002) 45: 4471-4484 [PMID:12238926] |
GtoPdb | - | - | 8.9 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2000) 361: 225-34 [PMID:10731034]; Neuropharmacology (1997) 36: 1157-65 [PMID:9364471]; J Med Chem (1994) 37: 3614-21 [PMID:7932588] |
ChEMBL | Binding affinity for adenosine A3 receptor as inhibition of [125I]AB-MECA binding to human receptor expressed in HEK 293 cells | B | 8.96 | pKi | 1.1 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 1767-1770 [PMID:9873431] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem (2009) 17: 8003-8011 [PMID:19879151] |
ChEMBL | Binding affinity for human Adenosine A3 receptor in CHO cells using [125I]-iodo-AB-MECA | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2003) 46: 3775-3777 [PMID:12930138] |
ChEMBL | Binding affinity to A3AR (unknown origin) | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem (2014) 22: 4257-4268 [PMID:24931275] |
ChEMBL | Displacement of [125I]ABA from human adenosine A3 receptor expressed in HEK cells | B | 9.2 | pKi | 0.64 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2416-2418 [PMID:16487705] |
ChEMBL | Displacement of [125I]I-AB-MEAC from human adenosine A3 receptor expressed in CHO cells | B | 9.42 | pKi | 0.38 | nM | Ki | Eur J Med Chem (2009) 44: 1377-1382 [PMID:18973967] |
ChEMBL | Displacement of [125I]AB-MECA from adenosine A3 receptor from HEK293 cell membranes | B | 9.48 | pKi | 0.33 | nM | Ki | J Med Chem (1998) 41: 3186-3201 [PMID:9703464] |
ChEMBL | Displacement of [125I]AB-MECA binding to Adenosine A3 receptor expressed in CHO cells | B | 9.48 | pKi | 0.33 | nM | Ki | J Med Chem (2004) 47: 5535-5540 [PMID:15481989] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 9.66 | pKi | 0.22 | nM | Ki | J Med Chem (2008) 51: 1764-1770 [PMID:18269230] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membrane after 90 mins | B | 9.66 | pKi | 0.22 | nM | Ki | Eur J Med Chem (2013) 69: 331-337 [PMID:24077183] |
ChEMBL | Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membrane | B | 9.66 | pKi | 0.22 | nM | Ki | J Med Chem (2012) 55: 1490-1499 [PMID:22257095] |
ChEMBL | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 9.66 |