p-chloroamphetamine [Ligand Id: 4592] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL358967 (Para-Chloroamphetamine, P-Chloroamphetamine)
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Inhibition of human dopamine transporter B 6.37 pIC50 424 nM IC50 Eur. J. Med. Chem. (2009) 44: 4862-4888 [PMID:19717215]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2005) 48: 2407-2419 [PMID:15801832]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Inhibition of human noradrenaline transporter B 6.68 pIC50 207 nM IC50 Eur. J. Med. Chem. (2009) 44: 4862-4888 [PMID:19717215]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosome B 6.74 pIC50 182 nM IC50 Eur. J. Med. Chem. (2009) 44: 4862-4888 [PMID:19717215]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]