p-chloroamphetamine [Ligand Id: 4592] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL358967 (Para-Chloroamphetamine, P-Chloroamphetamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Inhibition of human dopamine transporter | B | 6.37 | pIC50 | 424 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
| Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396] | ||||||||
| ChEMBL | Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2005) 48: 2407-2419 [PMID:15801832] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Inhibition of human noradrenaline transporter | B | 6.68 | pIC50 | 207 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosome | B | 6.74 | pIC50 | 182 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
