p-chloroamphetamine [Ligand Id: 4592] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL358967 (Para-Chloroamphetamine, P-Chloroamphetamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Inhibition of human dopamine transporter | B | 6.37 | pIC50 | 424 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
| Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396] | ||||||||
| ChEMBL | Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2005) 48: 2407-2419 [PMID:15801832] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Inhibition of human noradrenaline transporter | B | 6.68 | pIC50 | 207 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosome | B | 6.74 | pIC50 | 182 | nM | IC50 | Eur J Med Chem (2009) 44: 4862-4888 [PMID:19717215] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
