cordycepin [Ligand Id: 4630] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL305686 (3'-Deoxyadenosine, 9-cordyceposidoadenine, Cordycepin, Cordycepine, NSC-401022, NSC-63984)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • RNA-directed RNA polymerase in Hepacivirus hominis [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
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  • Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand B 4.82 pKi 15200 nM Ki J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL Affinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex B 4.82 pKi 15200 nM Ki J Med Chem (1997) 40: 3765-3772 [PMID:9371242]
ChEMBL Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligand B 5.15 pKi 7120 nM Ki J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL Affinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. B 5.15 pKi 7120 nM Ki J Med Chem (1997) 40: 3765-3772 [PMID:9371242]
RNA-directed RNA polymerase in Hepacivirus hominis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
ChEMBL Inhibition HCV NS5B-mediated RNA synthesis F 4.66 pIC50 22000 nM IC50 J Med Chem (2004) 47: 2283-2295 [PMID:15084127]
ChEMBL Inhibition HCV RNA replication F 4.34 pEC50 46000 nM EC50 J Med Chem (2004) 47: 2283-2295 [PMID:15084127]
Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1]
ChEMBL GSK_TCAKS: pIC50 CYP51 from Trypanosoma cruzi. F 4 pIC50 >100000 nM IC50 GSK Tres Cantos Anti-Kinetoplastid Screening (TCAKS) Data.

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]