cordycepin [Ligand Id: 4630] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL305686 (NSC-401022, Cordycepin, 3'-Deoxyadenosine, NSC-63984)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
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  • Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand B 4.82 pKi 15200 nM Ki J. Med. Chem. (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL Affinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex B 4.82 pKi 15200 nM Ki J. Med. Chem. (1997) 40: 3765-3772 [PMID:9371242]
ChEMBL Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligand B 5.15 pKi 7120 nM Ki J. Med. Chem. (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL Affinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. B 5.15 pKi 7120 nM Ki J. Med. Chem. (1997) 40: 3765-3772 [PMID:9371242]
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8]
ChEMBL Inhibition HCV NS5B-mediated RNA synthesis F 4.66 pIC50 22000 nM IC50 J. Med. Chem. (2004) 47: 2283-2295 [PMID:15084127]
ChEMBL Inhibition HCV RNA replication F 4.34 pEC50 46000 nM EC50 J. Med. Chem. (2004) 47: 2283-2295 [PMID:15084127]
Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1]
ChEMBL GSK_TCAKS: pIC50 CYP51 from Trypanosoma cruzi. F 4 pIC50 >100000 nM IC50 GSK Tres Cantos Anti-Kinetoplastid Screening (TCAKS) Data.

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]