MRS1191 [Ligand Id: 470] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1995014
  • A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542]
  • A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor in Rat [GtoPdb: 19] [UniProtKB: P30543]
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  • A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
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  • A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8]
  • A3 receptor in Rat [GtoPdb: 21] [UniProtKB: P28647]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb - - 5 pKi >10000 nM Ki . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099]
GtoPdb - - 4.4 pKi 40100 nM Ki . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 5 pKi >10000 nM Ki . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A2A receptor in Rat [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb - - 5 pKi >10000 nM Ki . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb - - 5 pKi >10000 nM Ki . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb - - 7.5 pKi - - - Neuropharmacology (1997) 36: 1157-65 [PMID:9364471];
J Med Chem (1996) 39: 4667-75 [PMID:8917655];
. A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)
A3 receptor in Rat [GtoPdb: 21] [UniProtKB: P28647]
GtoPdb - - 5.8 pKi - - - J Med Chem (1998) 41: 3186-201 [PMID:9703464];
. A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]