ChEMBL ligand: CHEMBL52609 (2'-deoxythymidine, Deoxyribothymidine, Doxribtimine, NSC-21548, Thymidin, Thymidine, Thymidinedeoxyriboside, Thymine-2-desoxyriboside, Zidovudine related compound d, Zidovudine related compound d rs)
Thymidine kinase in Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) [ChEMBL: CHEMBL1820] [UniProtKB: P06479] Thymidine kinase in Macacine herpesvirus 1 [ChEMBL: CHEMBL1075062] [UniProtKB: A3RLP8] There should be some charts here, you may need to enable JavaScript!
Thymidine kinase, cytosolic in Human [ChEMBL: CHEMBL2883] [UniProtKB: P04183] There should be some charts here, you may need to enable JavaScript!
Thymidylate kinase in Mycobacterium tuberculosis [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Thymidine kinase in Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1820] [UniProtKB: P06479]
ChEMBL	Binding affinity towards HSV-1 thymidine kinase	B	6	pIC50	1000	nM	IC50	J Med Chem (1996) 39: 4727-4737 [PMID:8941385]
Thymidine kinase in Macacine herpesvirus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075062] [UniProtKB: A3RLP8]
ChEMBL	Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation	B	5.39	pIC50	4100	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2028-2034 [PMID:17438061]
Thymidine kinase, cytosolic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2883] [UniProtKB: P04183]
ChEMBL	Inhibition of HSV-1 thymidine kinase	B	5.7	pKi	2000	nM	Ki	J Med Chem (1992) 35: 4214-4220 [PMID:1331461]
ChEMBL	Binding affinity constant against HSV-1 thymidine kinase	B	6.7	pKi	200	nM	Ki	J Med Chem (2003) 46: 5045-5054 [PMID:14584954]
ChEMBL	Inhibitory concentration against HSV-1 TK (WT) catalyzed [3H]-GCV phosphorylation	F	5.74	pIC50	1800	nM	IC50	J Med Chem (2002) 45: 4254-4263 [PMID:12213066]
ChEMBL	Inhibitory activity (50 uM) against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with gancicclovir	B	7.59	pIC50	26	nM	IC50	J Med Chem (2002) 45: 4254-4263 [PMID:12213066]
ChEMBL	Inhibitory activity (50 uM) against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with BVAraU	B	7.8	pIC50	16	nM	IC50	J Med Chem (2002) 45: 4254-4263 [PMID:12213066]
Thymidylate kinase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1]
ChEMBL	Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis	B	4.57	pKi	27000	nM	Ki	Bioorg Med Chem Lett (2003) 13: 3045-3048 [PMID:12941330]
ChEMBL	In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm)	B	4.57	pKi	27000	nM	Ki	J Med Chem (2003) 46: 3811-3821 [PMID:12930144]
ChEMBL	Binding affinity towards mycobacterium tuberculosis thymidine monophosphate kinase	B	4.57	pKi	27000	nM	Ki	J Med Chem (2005) 48: 2457-2468 [PMID:15801836]
ChEMBL	Inhibition of Mycobacterium tuberculosis TMPK by coupled spectrophotometric assay	B	4.57	pKi	27000	nM	Ki	J Med Chem (2004) 47: 6187-6194 [PMID:15566289]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant TMPK	B	4.57	pKi	27000	nM	Ki	Bioorg Med Chem (2008) 16: 6075-6085 [PMID:18467107]
ChEMBL	Inhibition of Mycobacterium tuberculosis TMPK using dTMP substrate and NADH by pyruvate kinase/lactate dehydrogenase coupling system based spectrophotometric assay	B	4.57	pKi	27000	nM	Ki	US-20080096907-A1. Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents (2008)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]