microcystin-LR [Ligand Id: 4735] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL444092
  • Protein phosphatase 2C alpha in Human [ChEMBL: CHEMBL2437] [UniProtKB: P35813]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform in Human [ChEMBL: CHEMBL4284] [UniProtKB: P63151]
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  • Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
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  • Serine-threonine protein phosphatase 2A regulatory subunit in Chicken [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
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  • Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
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  • protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775]
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  • protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Protein phosphatase 2C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2437] [UniProtKB: P35813]
ChEMBL Inhibitory concentration required against protein phosphatase 1 using pNPP assay B 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2003) 13: 2903-2906 [PMID:14611854]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Observed inhibition activity of the compounds against protein phosphatases 1 (PP1) B 8.93 pIC50 1.17 nM IC50 J Med Chem (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle B 10 pIC50 0.1 nM IC50 Bioorg Med Chem Lett (1993) 3: 1029-1034
Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4284] [UniProtKB: P63151]
ChEMBL Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A) B 10.19 pIC50 0.07 nM IC50 J Med Chem (1997) 40: 3199-3206 [PMID:9379439]
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
ChEMBL Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes B 10 pIC50 0.1 nM IC50 Bioorg Med Chem Lett (1993) 3: 1029-1034
Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
ChEMBL Inhibitory concentration required against protein phosphatase 2A using pNPP assay B 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2003) 13: 2903-2906 [PMID:14611854]
ChEMBL Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) B 10 pIC50 0.1 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
Serine/threonine-protein phosphatase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3425389] [UniProtKB: P53041]
ChEMBL Inhibition of PP5 (unknown origin) B 9 pIC50 1 nM IC50 J Med Chem (2021) 64: 8916-8938 [PMID:34156850]
Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in N124D B 6.7 pIC50 200 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in H248N B 7.46 pIC50 35 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R96A B 7.46 pIC50 35 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 9PP1) mutants by natural toxins in R221S B 7.54 pIC50 29 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208A B 8.72 pIC50 1.9 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272F B 9.1 pIC50 0.8 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127S B 9.25 pIC50 0.56 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type B 10.7 pIC50 0.02 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220V B 10.7 pIC50 0.02 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275R B 11 pIC50 0.01 nM IC50 J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775]
GtoPdb - - 10 pIC50 0.1 nM IC50 Br J Pharmacol (2022) 179: 65-83 [PMID:34519023]
protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136]
GtoPdb - - 10 pIC50 0.1 nM IC50 Bioorg Med Chem (1997) 5: 1739-50 [PMID:9354230]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]