piretanide [Ligand Id: 4742] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL349803 (Arelix, Arlix, HOE 118, HOE-118, Piretanide, S 73 4118, S-734118, S-73-4118)
  • Kidney-specific Na-K-Cl symporter in Human [GtoPdb: 968] [UniProtKB: Q13621]
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  • Basolateral Na-K-Cl symporter in Human [GtoPdb: 969] [UniProtKB: P55011]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kidney-specific Na-K-Cl symporter in Human [GtoPdb: 968] [UniProtKB: Q13621]
GtoPdb - - 5.97 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915]
Basolateral Na-K-Cl symporter in Human [GtoPdb: 969] [UniProtKB: P55011]
GtoPdb - - 5.62 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]