vesamicol [Ligand Id: 4759] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL20943
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
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  • Vesicular acetylcholine transporter in Torpedo californica [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
  • Vesicular acetylcholine transporter in Human [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
  • Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting method B 7.2 pKi 63.4 nM Ki J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting method B 7.56 pKi 27.4 nM Ki J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting B 7.66 pKi 22.1 nM Ki Bioorg. Med. Chem. (2012) 20: 4936-4941 [PMID:22831799]
Vesicular acetylcholine transporter in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
ChEMBL Displacement of [3H]vesamicol from Vesamicol receptor of Torpedo californica B 7.47 pIC50 34 nM IC50 J. Med. Chem. (1991) 34: 2638-2643 [PMID:1875353]
Vesicular acetylcholine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
GtoPdb - - 8.7 pKi 2 nM Ki Biochem Pharmacol (1995) 49: 791-7 [PMID:7702637]
ChEMBL Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (1989) 32: 1217-1230 [PMID:2724295]
ChEMBL Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles B 7.4 pIC50 40 nM IC50 J. Med. Chem. (1989) 32: 1217-1230 [PMID:2724295]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting method B 7.31 pKi 48.6 nM Ki J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DTG B 7.47 pKi 33.9 nM Ki Bioorg. Med. Chem. (2012) 20: 4936-4941 [PMID:22831799]
ChEMBL Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting B 7.48 pKi 32.9 nM Ki Bioorg. Med. Chem. (2012) 20: 4936-4941 [PMID:22831799]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]