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ChEMBL ligand: CHEMBL50880 (M-Iodobenzyltrozamicol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] | ||||||||
ChEMBL | Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain membrane homogenates after 90 mins by liquid scintillation counting | B | 7.04 | pKi | 92 | nM | Ki | J Med Chem (2011) 54: 5362-5372 [PMID:21732626] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand | B | 7.04 | pKi | 92 | nM | Ki | J Med Chem (1999) 42: 2862-2869 [PMID:10425095] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
ChEMBL | Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazocine (100 nM) | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (1999) 42: 2862-2869 [PMID:10425095] |
Vesicular acetylcholine transporter in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313] [UniProtKB: P81721] | ||||||||
ChEMBL | In vitro binding affinity to vesamicol receptor using [3H]vesamicol. | B | 10.2 | pKi | 0.06 | nM | Ki | J Med Chem (1994) 37: 2574-2582 [PMID:8057300] |
Vesicular acetylcholine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572] | ||||||||
ChEMBL | Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles | B | 9.89 | pKi | 0.13 | nM | Ki | J Med Chem (1997) 40: 3905-3914 [PMID:9397171] |
ChEMBL | Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT) | B | 9.89 | pKi | 0.13 | nM | Ki | J Med Chem (1999) 42: 2862-2869 [PMID:10425095] |
ChEMBL | Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrs | B | 9.89 | pKi | 0.13 | nM | Ki | J Med Chem (2011) 54: 5362-5372 [PMID:21732626] |
GtoPdb | - | - | 10.9 | pKi | 0.01 | nM | Ki | Biochem Pharmacol (1995) 49: 791-7 [PMID:7702637] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]