aminobenzovesamicol [Ligand Id: 4768] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL50880 (M-Iodobenzyltrozamicol)
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
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  • Vesicular acetylcholine transporter in Torpedo californica [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
  • Vesicular acetylcholine transporter in Human [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain membrane homogenates after 90 mins by liquid scintillation counting B 7.04 pKi 92 nM Ki J Med Chem (2011) 54: 5362-5372 [PMID:21732626]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity against Sigma opioid receptor type 1 in guinea pig brain membranes using [3H](+)-pentazocine as radioligand B 7.04 pKi 92 nM Ki J Med Chem (1999) 42: 2862-2869 [PMID:10425095]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL Binding affinity against Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG (DuPont-NEN) as radioligand in the presence of (+)-pentazocine (100 nM) B 6.72 pKi 190 nM Ki J Med Chem (1999) 42: 2862-2869 [PMID:10425095]
Vesicular acetylcholine transporter in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
ChEMBL In vitro binding affinity to vesamicol receptor using [3H]vesamicol. B 10.2 pKi 0.06 nM Ki J Med Chem (1994) 37: 2574-2582 [PMID:8057300]
Vesicular acetylcholine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
ChEMBL Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles B 9.89 pKi 0.13 nM Ki J Med Chem (1997) 40: 3905-3914 [PMID:9397171]
ChEMBL Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT) B 9.89 pKi 0.13 nM Ki J Med Chem (1999) 42: 2862-2869 [PMID:10425095]
ChEMBL Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrs B 9.89 pKi 0.13 nM Ki J Med Chem (2011) 54: 5362-5372 [PMID:21732626]
GtoPdb - - 10.9 pKi 0.01 nM Ki Biochem Pharmacol (1995) 49: 791-7 [PMID:7702637]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]