5-fluorouracil [Ligand Id: 4789] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL185 (Adrucil, Fluoro-uracil roche, Fluorouracil, 5.f.u., Accusite, Efudix, 5-FU, NSC-19893, RO 2-9757, RO-29757, Fluracil, Actikerall, RO-2-9757, Carac, Fluoroplex, Tolak, 5 FU, 5-Fluorouracil, Efudex)
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  • thymidylate synthetase/Thymidylate synthase in Mouse [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
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  • Uracil phosphoribosyltransferase in Escherichia coli (strain K12) [ChEMBL: CHEMBL2233621] [UniProtKB: P0A8F0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 4.8 pIC50 15848.93 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.1 pIC50 7943.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.2 pIC50 6309.57 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15 mins by liquid scintillation counting B 5 pIC50 >=10000 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting B 5.15 pIC50 7000 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting B 6.22 pIC50 600 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting B 6.66 pIC50 220 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting B 7.22 pIC50 60 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting B 7.7 pIC50 20 nM IC50 Eur. J. Med. Chem. (2011) 46: 993-1005 [PMID:21330014]
Uracil phosphoribosyltransferase in Escherichia coli (strain K12) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2233621] [UniProtKB: P0A8F0]
ChEMBL Inhibition of Escherichia coli K-12 MTCC 1302 UPRT activity by spectrophotometry B 4.89 pKi 13000 nM Ki Med Chem Res (2012) 21: 1149-1155

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]