5-fluorouracil [Ligand Id: 4789] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL185 (5-Fluorouracil, 5-fluoruracil, 5.f.u., 5 FU, 5-FU, Accusite, Actikerall, Adrucil, Carac, Efudex, Efudix, Fluoroplex, Fluorouracil, Fluoro-uracil roche, Fluorouracilum, Fluorouricil, Fluracil, NSC-19893, Phthoruracil, Queroplex, RO 2-9757, RO-2-9757, RO-29757, Tolak)
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  • thymidylate synthetase/Thymidylate synthase in Mouse [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
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  • Uracil phosphoribosyltransferase in Escherichia coli [ChEMBL: CHEMBL2233621] [UniProtKB: P0A8F0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 4.8 pIC50 15848.93 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.1 pIC50 7943.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.2 pIC50 6309.57 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15 mins by liquid scintillation counting B 5 pIC50 >=10000 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting B 5.15 pIC50 7000 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting B 6.22 pIC50 600 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting B 6.66 pIC50 220 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting B 7.22 pIC50 60 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
ChEMBL Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014]
Uracil phosphoribosyltransferase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2233621] [UniProtKB: P0A8F0]
ChEMBL Inhibition of Escherichia coli K-12 MTCC 1302 UPRT activity by spectrophotometry B 4.89 pKi 13000 nM Ki Med Chem Res (2012) 21: 1149-1155

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]