penicillin G [Ligand Id: 4796] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL29 (Benzylpenicillin, Bicillin, Penicillin-2, Pfizerpen-AS, J01CE01, NSC-193396, Benzylpenicillin, Penicillin G, Permapen, Crystapen G, Penicillin g)
  • Beta-lactamase TEM in Escherichia coli [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
  • Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase TEM in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
ChEMBL Inhibition constant (Ki) for TEM-1 beta-lactamase B 4.7 pKi 20000 nM Ki J. Med. Chem. (1988) 31: 370-374 [PMID:3257523]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells F 4.01 pKi 97600 nM Ki J. Pharmacol. Exp. Ther. (2002) 302: 666-671 [PMID:12130730]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cells F 4.28 pKi 52800 nM Ki J. Pharmacol. Exp. Ther. (2002) 300: 746-753 [PMID:11861777]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]