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ChEMBL ligand: CHEMBL1297 (53858, Fenoprofen, LILLY-53858, Nalfon, NSC-757813, Progesic) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 6.84 | pIC50 | 145 | nM | IC50 | DrugMatrix in vitro pharmacology data |
GtoPdb | - | - | 6.84 | pIC50 | 145 | nM | IC50 | National Toxicology Program: Dept of Health and Human Services.. DrugMatrix |
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208] | ||||||||
ChEMBL | Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay | B | 4.58 | pIC50 | 26300 | nM | IC50 | Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364] |
SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695] | ||||||||
GtoPdb | - | - | 4.57 | pIC50 | 27000 | nM | IC50 | Pharm Res (2006) 23: 1209-16 [PMID:16729224] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]