cephradine [Ligand Id: 4830] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1604 (SK-D-39304, SK&F-D39304, Velosef '250', Velosef '500', Velosef, Ecosporina, Cefradine, Nicef, Velosef '125', SQ-22022 [Dihydrate], SQ-22022, Anspor, SQ-11436, Cephradine)
  • Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
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  • Peptide transporter 1/Oligopeptide transporter small intestine isoform in Human [ChEMBL: CHEMBL4605] [GtoPdb: 984] [UniProtKB: P46059]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells F 4.19 pKi 65000 nM Ki Eur. J. Pharm. Biopharm. (2005) 59: 17-24 [PMID:15567297]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells F 4.33 pKi 47000 nM Ki Am. J. Physiol. (1997) 273: F706-F711 [PMID:9374833]
Peptide transporter 1/Oligopeptide transporter small intestine isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4605] [GtoPdb: 984] [UniProtKB: P46059]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells F 5.01 pKi 9800 nM Ki Eur. J. Pharm. Biopharm. (2005) 59: 17-24 [PMID:15567297]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]