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ChEMBL ligand: CHEMBL435 (Apo-hydro, Apresazide, Carozide, Chlorosulthiadil, Copalia-hct, Dafiro-hct, Dihydrochlorurite, Esidrex, Esidrix, Exforge-hct, Hctz, Hidrotiazida, Hydrochlorothiaizide, Hydrochlorothiazide, Hydrochlorothiazide intensol, Hydrochlorothiazidum, Hydro-d, Hydrodiuril, Hydrosaluric, Idrotiazide, Imprida-hct, Lotensin hct, Megadiuril, Microzide, Newtolide, NSC-53477, Oretic, Pantemon, Rasilez-hct, Servithiazid, SU-5879, Unipres, Vetidrex, Zide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.5 | pKi | 31.5 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523] |
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.4 | pKi | 394 | nM | Ki | Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172] |
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 8.14 | pKi | 7.2 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758] |
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.53 | pKi | 296 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758] |
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 6.48 | pKi | 328 | nM | Ki | J. Med. Chem. (2012) 55: 10742-10748 [PMID:23181552] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029] |
ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813] |
ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 526-531 [PMID:25533402] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015] |
ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523] |
ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863] |
ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758] |
ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377] |
ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803] |
ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 6.48 | pKi | 328 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 6.48 | pKi | 328 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 6.54 | pKi | 290 | nM | Ki | J. Med. Chem. (2012) 55: 10742-10748 [PMID:23181552] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2014) 24: 275-279 [PMID:24314394] |
ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813] |
ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 526-531 [PMID:25533402] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015] |
ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523] |
ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 3550-3555 [PMID:26174556] |
ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863] |
ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758] |
ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377] |
ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 1253-1259 [PMID:26832216] |
ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803] |
ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 6.54 | pKi | 290 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 6.54 | pKi | 290 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 5.37 | pKi | 4270 | nM | Ki | Bioorg. Med. Chem. Lett. (2014) 24: 275-279 [PMID:24314394] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]