noradrenaline [Ligand Id: 484] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL432
  • TA1 receptor/Trace amine-associated receptor 1 in Human [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0]
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
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  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
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  • D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0]
ChEMBL Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analysis F 4.91 pEC50 12200 nM EC50 ACS Med Chem Lett (2022) 13: 92-98 [PMID:35047111]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6 pKi - - - Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109]
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb - - 5.4 pKi - - - Mol Pharmacol (2004) 65: 1181-90 [PMID:15102946]
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 4.3 pKi - - - Nature (1991) 350: 614-9 [PMID:1826762]
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
GtoPdb - - 4.9 pKi - - - Nature (1991) 350: 614-9 [PMID:1826762]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]