linaclotide [Ligand Id: 5017] activity data from GtoPdb

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  • Guanylyl cyclase-C in Human [GtoPdb: 1750] [UniProtKB: P25092]
  • Guanylyl cyclase-C in Rat [GtoPdb: 1750] [UniProtKB: P23897]
1 _lig_chart_1 Guanylyl cyclase-C HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Guanylyl cyclase-C in Human [GtoPdb: 1750] [UniProtKB: P25092]
GtoPdb Competitive-inhibition of [125I]-STa binding to T84 colorectal carcinoma cells - 8.91 pKi 1.24 nM Ki Curr. Opin. Mol. Ther. (2007) 9: 403-10 [PMID:17694454];
Eur. J. Pharmacol. (2010) 649: 328-35 [PMID:20863829]
Guanylyl cyclase-C in Rat [GtoPdb: 1750] [UniProtKB: P23897]
GtoPdb Competitive-inhibition of [125I]-STa binding to rat intestinal mucosa - 8.38 pKi 4.2 nM Ki Eur. J. Pharmacol. (2010) 649: 328-35 [PMID:20863829]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.