muramyl dipeptide [Ligand Id: 5024] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL369794 (muramyldipeptide)
  • nucleotide binding oligomerization domain containing 2/Nucleotide-binding oligomerization domain-containing protein 2 in Human [ChEMBL: CHEMBL1293266] [GtoPdb: 1763] [UniProtKB: Q9HC29]
  • This target only has 0 pki data point
  • 0
1 CHEMBL369794_lig_chart_1 Nucleotide-binding oligomerization domain-containing protein 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nucleotide binding oligomerization domain containing 2/Nucleotide-binding oligomerization domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293266] [GtoPdb: 1763] [UniProtKB: Q9HC29]
ChEMBL Agonist activity at human NOD2 expressed in HEK-Blue cells assessed as induction of NF-kB transcriptional activity after 18 hrs by SEAP reporter gene assay B 7.04 pEC50 92 nM EC50 J Med Chem (2018) 61: 2707-2724 [PMID:29543461]
ChEMBL Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay B 7.34 pEC50 46 nM EC50 Eur. J. Med. Chem. (2016) 116: 1-12 [PMID:27039337]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]