(-)-noradrenaline [Ligand Id: 505] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1437 (R-norepinephrine, Norepinephrine, Levophed)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
  • Alpha-1b adrenergic receptor in Hamster [ChEMBL: CHEMBL3122] [UniProtKB: P18841]
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
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  • α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Mouse [ChEMBL: CHEMBL4075] [GtoPdb: 25] [UniProtKB: Q01338]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Mouse [ChEMBL: CHEMBL4826] [GtoPdb: 27] [UniProtKB: Q01337]
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Rat [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
  • Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • Beta-2 adrenergic receptor in Dog [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
  • Beta-2 adrenergic receptor in Bovine [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
  • β2-adrenoceptor/Beta-2 adrenergic receptor in Rat [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608]
  • Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
  • β3-adrenoceptor/Beta-3 adrenergic receptor in Rat [ChEMBL: CHEMBL4031] [GtoPdb: 30] [UniProtKB: P26255]
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101 B 5.82 pKi 1500 nM Ki J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
GtoPdb - - 6.4 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Br J Pharmacol (1999) 127: 962-8 [PMID:10433504];
Br J Pharmacol (1995) 116: 1611-8 [PMID:8564227]
ChEMBL In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate F 5.66 pEC50 2187.76 nM EC50 J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
ChEMBL Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay B 8.04 pEC50 9.1 nM EC50 J. Med. Chem. (2015) 58: 6048-6057 [PMID:26125514]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity towards bovine clonal Alpha-1A adrenergic receptor B 6.35 pKi 446.68 nM Ki J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL Binding affinity towards Alpha-1A adrenergic receptor in rat submaxillary glands B 6.55 pKi 281.84 nM Ki J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
ChEMBL In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens F 5.93 pEC50 1174.9 nM EC50 J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Displacement of [3H]prazosin from human adrenergic Alpha-1B receptor expressed in CHO cell membrane B 4.69 pKi 20400 nM Ki Bioorg. Med. Chem. (2009) 17: 7987-7992 [PMID:19857969]
GtoPdb - - 6.2 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358]
Alpha-1b adrenergic receptor in Hamster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3122] [UniProtKB: P18841]
ChEMBL Binding affinity towards hamster clonal Alpha-1B adrenergic receptor B 6.58 pKi 263.03 nM Ki J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen F 4.99 pEC50 10232.93 nM EC50 J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb - - 7.4 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Br J Pharmacol (1995) 116: 1611-8 [PMID:8564227]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
GtoPdb - - 6.3 pKi - - - Mol Pharmacol (1994) 46: 929-36 [PMID:7969082]
ChEMBL Binding affinity towards rat clonal Alpha-1D adrenergic receptor B 7.65 pKi 22.39 nM Ki J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
ChEMBL In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta F 7.92 pEC50 12.02 nM EC50 J. Med. Chem. (1996) 39: 4116-4119 [PMID:8831777]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity for human Alpha-2A adrenergic receptor B 7.18 pKi 66 nM Ki J. Med. Chem. (1996) 39: 1193-1195 [PMID:8632424]
GtoPdb - - 7.4 pKi - - - Biochim Biophys Acta (1998) 1448: 135-46 [PMID:9824686];
Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
ChEMBL Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry F 6.43 pEC50 371.54 nM EC50 J. Med. Chem. (2009) 52: 7319-7322 [PMID:19886609]
ChEMBL Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation F 6.43 pEC50 371.54 nM EC50 J. Med. Chem. (2007) 50: 3964-3968 [PMID:17630725]
ChEMBL Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification F 6.43 pEC50 371.54 nM EC50 J. Med. Chem. (2008) 51: 4289-4299 [PMID:18578476]
ChEMBL Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry F 6.43 pEC50 371.54 nM EC50 J. Med. Chem. (2004) 47: 6160-6173 [PMID:15566287]
ChEMBL Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay F 6.89 pEC50 128.82 nM EC50 Eur. J. Med. Chem. (2014) 87: 386-397 [PMID:25282262]
ChEMBL Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting F 6.93 pEC50 118 nM EC50 Bioorg. Med. Chem. (2012) 20: 108-116 [PMID:22172308]
ChEMBL Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting F 6.96 pEC50 110 nM EC50 Bioorg. Med. Chem. (2011) 19: 321-329 [PMID:21129985]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4075] [GtoPdb: 25] [UniProtKB: Q01338]
ChEMBL Binding affinity to mouse alpha-2A receptor expressed in COS7 cells B 5.24 pKi 5800 nM Ki US-20050059664-A1. Novel methods for identifying improved, non-sedating alpha-2 agonists (2005)
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 6 pKi - - - Biochim Biophys Acta (1998) 1448: 135-46 [PMID:9824686];
Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
ChEMBL Agonist activity at human adrenergic alpha-2B receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry F 7.21 pEC50 61.66 nM EC50 J. Med. Chem. (2004) 47: 6160-6173 [PMID:15566287]
ChEMBL Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation F 7.21 pEC50 61.66 nM EC50 J. Med. Chem. (2007) 50: 3964-3968 [PMID:17630725]
ChEMBL Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells F 7.21 pEC50 61.66 nM EC50 J. Med. Chem. (2008) 51: 4289-4299 [PMID:18578476]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
ChEMBL Binding affinity for rat Alpha-2B adrenergic receptor B 7.11 pKi 78 nM Ki J. Med. Chem. (1996) 39: 1193-1195 [PMID:8632424]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 6.8 pKi - - - Biochim Biophys Acta (1998) 1448: 135-46 [PMID:9824686];
Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
ChEMBL Binding affinity for human Alpha-2C adrenergic receptor B 7.2 pKi 63 nM Ki J. Med. Chem. (1996) 39: 1193-1195 [PMID:8632424]
ChEMBL Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry F 6.1 pEC50 794.33 nM EC50 J. Med. Chem. (2004) 47: 6160-6173 [PMID:15566287]
ChEMBL Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation F 6.1 pEC50 794.33 nM EC50 J. Med. Chem. (2007) 50: 3964-3968 [PMID:17630725]
ChEMBL Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification F 6.1 pEC50 794.33 nM EC50 J. Med. Chem. (2008) 51: 4289-4299 [PMID:18578476]
ChEMBL Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry F 6.1 pEC50 794.33 nM EC50 J. Med. Chem. (2009) 52: 7319-7322 [PMID:19886609]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4826] [GtoPdb: 27] [UniProtKB: Q01337]
ChEMBL Binding affinity to mouse alpha-2C receptor expressed in COS7 cells B 6.19 pKi 650 nM Ki US-20050059664-A1. Novel methods for identifying improved, non-sedating alpha-2 agonists (2005)
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6 pKi - - - Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109];
Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417]
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
ChEMBL Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes B 4.59 pKi 26000 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes B 5.57 pKi 2700 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes B 5.8 pKi 1600 nM Ki J. Med. Chem. (1993) 36: 3947-3955 [PMID:8254623]
ChEMBL Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes B 5.89 pKi 1300 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand B 6.9 pKi 126 nM Ki J. Med. Chem. (1993) 36: 3077-3086 [PMID:8230093]
ChEMBL Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain B 6.9 pKi 126 nM Ki J. Med. Chem. (1992) 35: 1009-1018 [PMID:1313109]
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenolol B 6.4 pKi 400 nM Ki J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
ChEMBL Effective dose required to stimulate contractions in isolated guinea pig atrium. F 5 pEC50 10000 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria F 6.46 pEC50 350 nM EC50 J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
ChEMBL Effective concentration for Beta-1 adrenergic receptor mediated inhibition of neurotransmission in field-stimulated reserpine pretreated guinea pig ileum. F 7.52 pEC50 30 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM B 5.4 pKd 3981.07 nM Kd Bioorg. Med. Chem. Lett. (2013) 23: 5376-5381 [PMID:23954364]
ChEMBL Binding affinity to human adrenergic beta2 receptor B 5.4 pKd 3980 nM Kd Eur. J. Med. Chem. (2009) 44: 2840-2846 [PMID:19168263]
ChEMBL Displacement of [3H]prazosin from human adrenergic beta2 receptor expressed in CHO cell membrane B 4.01 pKi 96700 nM Ki Bioorg. Med. Chem. (2009) 17: 7987-7992 [PMID:19857969]
GtoPdb - - 4.8 pKi - - - Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109];
Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417]
ChEMBL Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells B 5.48 pKi 3300 nM Ki Bioorg. Med. Chem. (2016) 24: 2641-2653 [PMID:27132867]
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
ChEMBL Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes B 4.57 pKi 27000 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes B 4.96 pKi 11000 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes B 5.3 pKi 5000 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL Tested for binding affinity against beta-2 adrenergic receptor in bovine lung using [3H]DHA as radioligand B 5.22 pKi 6000 nM Ki J. Med. Chem. (1993) 36: 3077-3086 [PMID:8230093]
ChEMBL Compound was evaluated for beta adrenergic binding affinity towards beta-2 receptor of bovine lung B 5.22 pKi 6000 nM Ki J. Med. Chem. (1992) 35: 1009-1018 [PMID:1313109]
β2-adrenoceptor/Beta-2 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608]
ChEMBL Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes B 5.38 pKi 4200 nM Ki J. Med. Chem. (1993) 36: 3947-3955 [PMID:8254623]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL Activity for Beta-2 adrenergic receptor was assessed from effect on relaxation of guinea pig trachea. F 4.52 pEC50 30000 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL Activity for Beta-2 adrenergic receptor was assessed from effect on relaxation of guinea pig trachea. F 6.67 pEC50 213 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb - - 6.3 pKi - - - Annu Rev Pharmacol Toxicol (1997) 37: 421-50 [PMID:9131260];
Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417];
Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619]
ChEMBL Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay F 8.2 pEC50 6.3 nM EC50 Bioorg. Med. Chem. (2008) 16: 2473-2488 [PMID:18083578]
ChEMBL Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method F 8.26 pEC50 5.5 nM EC50 Bioorg. Med. Chem. (2008) 16: 2473-2488 [PMID:18083578]
β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
GtoPdb - - 3.8 pKi - - - Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619]
β3-adrenoceptor/Beta-3 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4031] [GtoPdb: 30] [UniProtKB: P26255]
GtoPdb - - 4.2 pKi - - - Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619]
ChEMBL Activity for beta 3-adrenoceptor was assessed from effect on stimulation of lipolysis in rat adipocytes. F 4 pEC50 100000 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL Effective dose for contraction of reserpine-pretreated rat vas deferens F 5.8 pEC50 1580 nM EC50 J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells B 4.3 pKd 50000 nM Kd J. Med. Chem. (1996) 39: 850-859 [PMID:8632409]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells B 5.89 pKi 1300 nM Ki Bioorg. Med. Chem. (2016) 24: 2641-2653 [PMID:27132867]
Nischarin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3923] [UniProtKB: Q9Y2I1]
ChEMBL Displacement of [3H]-clonidine from bovine imidazoline receptor I-1 B 4 pKi >100000 nM Ki J. Med. Chem. (1996) 39: 1193-1195 [PMID:8632424]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting B 5 pKi >10000 nM Ki Bioorg. Med. Chem. (2012) 20: 4936-4941 [PMID:22831799]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]