2'-deoxyadenosine [Ligand Id: 5109] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL449329 (2'-Deoxyadenosine)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • adenylyl cyclase 5/Adenylate cyclase type V in Rat [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand B 4.63 pKi 23300 nM Ki J. Med. Chem. (1995) 38: 4000-4006 [PMID:7562934]
adenylyl cyclase 5/Adenylate cyclase type V in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400]
ChEMBL Compound was evaluated for inhibition of adenylate cyclase from rat brain B 4.82 pIC50 15000 nM IC50 J. Med. Chem. (2004) 47: 1207-1213 [PMID:14971900]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]