5'-inosine monophosphate [Ligand Id: 5124] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1207374 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Hypoxanthine-guanine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2360] [UniProtKB: P00492] | ||||||||
| ChEMBL | Inhibition of human HGPRT | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (2015) 58: 4822-4838 [PMID:25915781] |
| TAS1R3/TAS1R1/T1R1/T1R3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3832641] [GtoPdb: 658, 656] [UniProtKB: Q7RTX0, Q7RTX1] | ||||||||
| ChEMBL | Activation of T1R1/T1R3 Receptor by Nucleotide Derivatives (alanine): The concentration of alanine is 20 mM. | B | 4.15 | pEC50 | 70000 | nM | EC50 | US-11185100-B2. Methods for modulating taste receptors (2021) |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
