ChEMBL ligand: CHEMBL247378 (7-Nitroindazole)
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric oxide synthase, endothelial in Rat [ChEMBL: CHEMBL1075230] [GtoPdb: 1249] [UniProtKB: Q62600] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] Nitric-oxide synthase, endothelial in Bovine [ChEMBL: CHEMBL4802] [UniProtKB: P29473] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
GtoPdb	-	-	5.3	pIC50	5000	nM	IC50	Br J Pharmacol (1993) 110: 225-8 [PMID:7693279]
ChEMBL	Inhibitory activity against human neuronal nitric oxide synthase (nNOS)	B	5.54	pIC50	2870	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210]
ChEMBL	In vitro inhibition of human neuronal nitric oxide synthase	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
ChEMBL	Inhibition of NOS1	B	6.15	pIC50	710	nM	IC50	Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL	Inhibition of rat recombinant nNOS expressed in Saccharomyces cerevisiae assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay	B	4.57	pIC50	27000	nM	IC50	Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449]
ChEMBL	Inhibition of rat brain recombinant nNOS	B	4.6	pIC50	25000	nM	IC50	Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134]
ChEMBL	Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)	B	5.67	pIC50	2120	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by neuronal NOS from rat cerebellum.	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576
ChEMBL	In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1153-1156 [PMID:11354365]
ChEMBL	Inhibition of rat neuronal NOS	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3177-3180 [PMID:17395463]
ChEMBL	Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visible spectrophotometer analysis	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2011) 19: 3935-3944 [PMID:21665485]
Endothelial NOS/Nitric oxide synthase, endothelial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075230] [GtoPdb: 1249] [UniProtKB: Q62600]
ChEMBL	Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 mins	B	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2019) 168: 491-514 [PMID:30851693]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL	Tested to inhibit the conversion of [3H]-L-arginine to [3H]L-citrulline catalyzed by endothelial NOS from human umbilical vein endothelial cells.	B	4.44	pIC50	36000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576
ChEMBL	In vitro inhibition of human endothelial nitric oxide synthase	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
ChEMBL	Inhibitory activity against human endothelial nitric oxide synthase (eNOS)	B	5.72	pIC50	1890	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2569-2572 [PMID:10498210]
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473]
ChEMBL	Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay	B	4.39	pIC50	41000	nM	IC50	Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449]
ChEMBL	Inhibition of bovine recombinant eNOS	B	4.46	pIC50	35000	nM	IC50	Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.	B	4.62	pIC50	24000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576
ChEMBL	Inhibition of NOS2	B	5.24	pIC50	5800	nM	IC50	Bioorg Med Chem (2009) 17: 6180-6187 [PMID:19679481]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL	Inhibition of mouse recombinant iNOS	B	4.3	pIC50	50000	nM	IC50	Bioorg Med Chem (2008) 16: 5962-5973 [PMID:18502134]
ChEMBL	Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioactive assay	B	4.4	pIC50	40000	nM	IC50	Eur J Med Chem (2009) 44: 2877-2887 [PMID:19144449]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells	B	4.7	pIC50	20000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]