ARP100 [Ligand Id: 5140] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL181244
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP16/Matrix metalloproteinase 16 in Human [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Inhibition of TACE B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Inhibition of human matrix metalloprotease-1 B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of MMP1 B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL Inhibition of MMP1 B 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of MMP1 by fluorometric assay B 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2010) 53: 2622-2635 [PMID:20180536]
ChEMBL Inhibition of MMP1-mediated collagen degradation by SDS-PAGE B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of MMP13 B 7.7 pKi 20 nM Ki J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of MMP13 B 7.35 pIC50 45 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of MMP13-mediated collagen degradation by SDS-PAGE B 7.6 pIC50 25 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of human matrix metalloprotease-14 B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of human recombinant MMP14 B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of human recombinant MMP14 by fluorometric assay B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (2010) 53: 2622-2635 [PMID:20180536]
ChEMBL Inhibition of human matrix metalloprotease-14 B 6.08 pIC50 >833 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
ChEMBL Inhibition of human recombinant MMP16 B 6.05 pIC50 900 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of MMP2 B 7.89 pKi 13 nM Ki J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of human matrix metalloprotease-2 B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of MMP2 B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL Inhibition of MMP2 B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of MMP2 by fluorometric assay B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2010) 53: 2622-2635 [PMID:20180536]
ChEMBL Inhibition of MMP2 (unknown origin) B 7.92 pIC50 12 nM IC50 Eur. J. Med. Chem. (2013) 60: 89-100 [PMID:23287054]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of MMP3 B 5.23 pIC50 5900 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of human matrix metalloprotease-3 B 5.35 pIC50 4500 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of MMP3 B 5.35 pIC50 4500 nM IC50 Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL Inhibition of MMP3 (unknown origin) B 5.35 pIC50 4500 nM IC50 Eur. J. Med. Chem. (2013) 60: 89-100 [PMID:23287054]
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL Inhibition of human matrix metalloprotease-7 B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of MMP7 B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of MMP8 B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of human matrix metalloprotease-9 B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1321-1326 [PMID:15713379]
ChEMBL Inhibition of MMP9 B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
ChEMBL Inhibition of MMP9 B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2009) 52: 4757-4773 [PMID:19606871]
ChEMBL Inhibition of MMP9 by fluorometric assay B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2010) 53: 2622-2635 [PMID:20180536]
ChEMBL Inhibition of MMP9 (unknown origin) B 6.7 pIC50 200 nM IC50 Eur. J. Med. Chem. (2013) 60: 89-100 [PMID:23287054]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]