ARP100 [Ligand Id: 5140] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL181244 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of TACE | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP-1 (unknown origin) activity using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 4 hrs followed by substrate addition for 4 hrs by fluorimetric assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
| ChEMBL | Inhibition of MMP1 | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP1 by fluorometric assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP1-mediated collagen degradation by SDS-PAGE | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of MMP13 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP13 | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP13-mediated collagen degradation by SDS-PAGE | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-14 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of human recombinant MMP14 | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human recombinant MMP14 by fluorometric assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of human matrix metalloprotease-14 | B | 6.08 | pIC50 | >833 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Inhibition of human recombinant MMP16 | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human matrix metalloprotease-2 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP2 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP2 | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP2 by fluorometric assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP2 (unknown origin) | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
| ChEMBL | Inhibition of MMP-2 (unknown origin) activity using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 4 hrs followed by substrate addition for 4 hrs by fluorimetric assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of MMP3 | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human matrix metalloprotease-3 | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP3 | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP3 (unknown origin) | B | 5.35 | pIC50 | 4500 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
| ChEMBL | Inhibition of MMP-3 (unknown origin) activity using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 4 hrs followed by substrate addition for 4 hrs by fluorimetric assay | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-7 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP7 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP-7 (unknown origin) activity using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 4 hrs followed by substrate addition for 4 hrs by fluorimetric assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-9 | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP9 | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP9 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP9 by fluorometric assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP9 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
| ChEMBL | Inhibition of MMP-9 (unknown origin) activity using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 4 hrs followed by substrate addition for 4 hrs by fluorimetric assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2022) 65: 10709-10754 [PMID:35969157] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
