ARP100 [Ligand Id: 5140] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL181244 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of TACE | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP1 | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP1 by fluorometric assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP1-mediated collagen degradation by SDS-PAGE | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of MMP13 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP13 | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP13-mediated collagen degradation by SDS-PAGE | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-14 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of human recombinant MMP14 | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human recombinant MMP14 by fluorometric assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of human matrix metalloprotease-14 | B | 6.08 | pIC50 | >833 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Inhibition of human recombinant MMP16 | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human matrix metalloprotease-2 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP2 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP2 | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP2 by fluorometric assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP2 (unknown origin) | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of MMP3 | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of human matrix metalloprotease-3 | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP3 | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP3 (unknown origin) | B | 5.35 | pIC50 | 4500 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-7 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP7 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of human matrix metalloprotease-9 | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1321-1326 [PMID:15713379] |
| ChEMBL | Inhibition of MMP9 | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP9 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2009) 52: 4757-4773 [PMID:19606871] |
| ChEMBL | Inhibition of MMP9 by fluorometric assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 2622-2635 [PMID:20180536] |
| ChEMBL | Inhibition of MMP9 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2013) 60: 89-100 [PMID:23287054] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
