esculetin [Ligand Id: 5180] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL244743 (6,7-Dihydroxycoumarin, Esculetin)
  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
  • This target only has 0 pki data point
1 CHEMBL244743_lig_chart_1 Aldose reductase Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
  • This target only has 1 pki data point
2 CHEMBL244743_lig_chart_2 Carbonic anhydrase IX Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
  • This target only has 1 pki data point
3 CHEMBL244743_lig_chart_3 Carbonic anhydrase XII Human
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  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • This target only has 0 pki data point
4 CHEMBL244743_lig_chart_4 Cyclooxygenase-1 Human
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  • Sorbitol dehydrogenase in Human [ChEMBL: CHEMBL2275] [UniProtKB: Q00796]
  • This target only has 0 pki data point
5 CHEMBL244743_lig_chart_5 Sorbitol dehydrogenase Human
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
  • This target only has 0 pki data point
6 CHEMBL244743_lig_chart_6 Xanthine dehydrogenase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis B 4.17 pIC50 67200 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 5630-5633 [PMID:20805028]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay B 7.44 pKi 36.4 nM Ki Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay B 8.03 pKi 9.3 nM Ki Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 B 4.24 pIC50 57000 nM IC50 J. Nat. Prod. (2005) 68: 985-991 [PMID:16038536]
Sorbitol dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2275] [UniProtKB: Q00796]
ChEMBL Inhibition sorbitol dehydrogenase by spectrophotometric analysis B 4.08 pIC50 82900 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 5630-5633 [PMID:20805028]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase B 5.09 pIC50 8200 nM IC50 Eur. J. Med. Chem. (2007) 42: 1028-1031 [PMID:17316915]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]