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ChEMBL ligand: CHEMBL261491 (Go-6893) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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L-type calcium channel alpha 1C/beta 2A in Rabbit (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3638171] [UniProtKB: P15381, P54288] | ||||||||
ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in human HEK293 cells transfected with rabbit L-type calcium channel subunits | F | 4.7 | pIC50 | 20000 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
protein kinase C zeta in Human [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]