JNJ1661010 [Ligand Id: 5206] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL460273 (JNJ-1661010) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of human FAAH preincubated for 10 mins | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH preincubated for 20 mins | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of FAAH | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4241-4244 [PMID:19515560] |
| ChEMBL | Inhibition of FAAH | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4674-4685 [PMID:21764305] |
| GtoPdb | - | - | 7.8 | pIC50 | 15.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-43 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH preincubated for 40 mins | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH after 60 mins | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2013) 21: 28-41 [PMID:23218778] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of rat FAAH preincubated for 20 mins | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of rat FAAH | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4674-4685 [PMID:21764305] |
| ChEMBL | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2492-2496 [PMID:21392988] |
| Fatty acid amide hydrolase-2 in Human [GtoPdb: 1401] [UniProtKB: Q6GMR7] | ||||||||
| GtoPdb | 20 min preincubation | - | 5.24 | pIC50 | 5700 | nM | IC50 | Anesth Analg (2009) 108: 316-29 [PMID:19095868] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
