BRL 44408 [Ligand Id: 525] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL216097 (BRL-44408)
  • α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
1 CHEMBL216097_lig_chart_1 α2A-adrenoceptor Human
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
2 CHEMBL216097_lig_chart_2 α2B-adrenoceptor Human
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
3 CHEMBL216097_lig_chart_3 α2C-adrenoceptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb - - 8.8 pKi - - - J. Pharmacol. Exp. Ther. (1994) 271: 1558-65 [PMID:7996470];
Eur. J. Pharmacol. (1989) 168: 381-6 [PMID:2573535]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 6.2 pKi - - - J. Pharmacol. Exp. Ther. (1994) 271: 1558-65 [PMID:7996470]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 6.8 pKi - - - J. Pharmacol. Exp. Ther. (1994) 271: 1558-65 [PMID:7996470]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]