RHC80267 [Ligand Id: 5255] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL158897 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of recombinant FAAH transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.15 | pIC50 | 70000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assay | B | 5.65 | pIC50 | 2240 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638] |
| PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093] | ||||||||
| ChEMBL | Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| LIP1, secretory lipase (Family 3) in Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3608197] [UniProtKB: A8PUY1] | ||||||||
| ChEMBL | Inhibition of Malassezia globosa CBS 7966 LIP1 using pNPA substrate | B | 4.12 | pIC50 | 75250 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3464-3467 [PMID:26199121] |
| αβ-Hydrolase 12/Monoacylglycerol lipase ABHD12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5516] [GtoPdb: 3070] [UniProtKB: Q8N2K0] | ||||||||
| ChEMBL | Inhibition of recombinant ABHD12 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Neutral cholesterol ester hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5048] [UniProtKB: Q6PIU2] | ||||||||
| ChEMBL | Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Protein BAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6168] [UniProtKB: O95870] | ||||||||
| ChEMBL | Inhibition of recombinant BAT5 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.64 | pIC50 | 23000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2] | ||||||||
| ChEMBL | Inhibition of human DAGLalpha | B | 4.19 | pIC50 | 65000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638] |
| GtoPdb | - | - | 4.19 | pIC50 | 65000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-92 [PMID:22738638] |
| ChEMBL | Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic surrogate substrate assay | B | 4.6 | pIC50 | 25118.86 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666] |
| ChEMBL | Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surrogate substrate assay | B | 5.3 | pIC50 | 5011.87 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666] |
| ChEMBL | Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| diacylglycerol lipase β/Sn1-specific diacylglycerol lipase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5521] [GtoPdb: 1397] [UniProtKB: Q8NCG7] | ||||||||
| ChEMBL | Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cells | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
