SCH51866 [Ligand Id: 5270] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628659 (SCH-51866)
  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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  • phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750]
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  • phosphodiesterase 1B in Human [GtoPdb: 1295] [UniProtKB: Q01064]
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  • phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123]
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  • phosphodiesterase 7B in Human [GtoPdb: 1306] [UniProtKB: Q9NP56]
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  • phosphodiesterase 9A in Human [GtoPdb: 1309] [UniProtKB: O76083]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb - - 7.2 pIC50 63.1 nM IC50 J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086]
ChEMBL Inhibition of PDE5 (unknown origin) B 7.22 pIC50 60 nM IC50 J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750]
GtoPdb - - 7.2 pIC50 63.1 nM IC50 J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086]
phosphodiesterase 1B in Human [GtoPdb: 1295] [UniProtKB: Q01064]
GtoPdb - - 7.2 pIC50 63.1 nM IC50 J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086]
phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123]
GtoPdb - - 7.2 pIC50 63.1 nM IC50 J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086]
phosphodiesterase 7B in Human [GtoPdb: 1306] [UniProtKB: Q9NP56]
GtoPdb - - 5.8 pIC50 1580 nM IC50 Biochem Biophys Res Commun (2000) 271: 575-83 [PMID:10814504]
phosphodiesterase 9A in Human [GtoPdb: 1309] [UniProtKB: O76083]
GtoPdb - - 5.8 pIC50 1580 nM IC50 J Biol Chem (1998) 273: 15559-64 [PMID:9624146]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]