VU0364739 [Ligand Id: 5287] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1254577
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
ChEMBL Inhibition of PLD1 in human calu1 cells B 5.82 pIC50 1500 nM IC50 J Med Chem (2010) 53: 6706-6719 [PMID:20735042]
ChEMBL Inhibition of PLD1 (unknown origin) B 5.82 pIC50 1500 nM IC50 Bioorg Med Chem Lett (2018) 28: 3670-3673 [PMID:30528979]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of human GST-tagged PLD2A in human HEK293 cells B 7.7 pIC50 20 nM IC50 J Med Chem (2010) 53: 6706-6719 [PMID:20735042]
ChEMBL Inhibition of PLD2 (unknown origin) B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2018) 28: 3670-3673 [PMID:30528979]
GtoPdb - - 7.7 pIC50 19.9 nM IC50 J Med Chem (2010) 53: 6706-19 [PMID:20735042]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]