VU0364739 [Ligand Id: 5287] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1254577
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
ChEMBL Inhibition of PLD1 in human calu1 cells B 5.82 pIC50 1500 nM IC50 J. Med. Chem. (2010) 53: 6706-6719 [PMID:20735042]
ChEMBL Inhibition of PLD1 (unknown origin) B 5.82 pIC50 1500 nM IC50 Bioorg Med Chem Lett (2018) 28: 3670-3673 [PMID:30528979]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of human GST-tagged PLD2A in human HEK293 cells B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2010) 53: 6706-6719 [PMID:20735042]
ChEMBL Inhibition of PLD2 (unknown origin) B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2018) 28: 3670-3673 [PMID:30528979]
GtoPdb - - 7.7 pIC50 19.9 nM IC50 J Med Chem (2010) 53: 6706-19 [PMID:20735042]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]