YC-1 [Ligand Id: 5291] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL333985
  • Hypoxia-inducible factor 1 alpha in Human [ChEMBL: CHEMBL4261] [UniProtKB: Q16665]
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  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Hypoxia-inducible factor 1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4261] [UniProtKB: Q16665]
ChEMBL Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assay B 4.52 pIC50 >30000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Hep3B cells by reporter gene assay B 4.86 pIC50 13800 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase reporter gene assay B 5.04 pIC50 9210 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3166-3169 [PMID:19435661]
ChEMBL Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human AGS cells by reporter gene assay B 5.7 pIC50 2000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assay B 5.82 pIC50 1500 nM IC50 ACS Med. Chem. Lett. (2013) 4: 297-301 [PMID:24900662]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL Inhibition of PDE5 from platelets B 4.5 pIC50 31900 nM IC50 J. Med. Chem. (2001) 44: 3746-3749 [PMID:11606139]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.2 pIC50 6309.57 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]