[3H](-)CGP 12177 [Ligand Id: 531] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL36060 (CGP-12177A)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 9.2 pKd - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 525-32 [PMID:15060759];
Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]
GtoPdb - - 9.9 pKd - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 525-32 [PMID:15060759]
ChEMBL Inhibition of I-iodocyanopindolol binding to human beta 1 adrenergic receptors B 9.6 pKi 0.25 nM Ki J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Inhibition of I-iodocyanopindolol binding to human beta 2 adrenergic receptors B 10 pKi 0.1 nM Ki J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]