N-ethylmaleimide [Ligand Id: 5335] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL8211
There should be some charts here, you may need to enable JavaScript!
  • monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
  • monoacylglycerol lipase/Monoglyceride lipase in Rat [ChEMBL: CHEMBL3321] [GtoPdb: 1399] [UniProtKB: Q8R431]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysis B 4.33 pIC50 46773.51 nM IC50 J Med Chem (2017) 60: 839-885 [PMID:27996267]
monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
ChEMBL Displacement of [3H]2-OG from human MGL by liquid scintillation counting B 4.78 pIC50 16600 nM IC50 J Med Chem (2009) 52: 7410-7420 [PMID:19583260]
monoacylglycerol lipase/Monoglyceride lipase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3321] [GtoPdb: 1399] [UniProtKB: Q8R431]
ChEMBL Inhibition of rat cerebellar membranes MAGL-like activity preincubated for 30 mins followed by 2-AG substrate addition after 90 mins by HPLC analysis B 4.28 pIC50 53000 nM IC50 J Med Chem (2017) 60: 4-46 [PMID:27766867]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]