okadaic acid [Ligand Id: 5349] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL280487
There should be some charts here, you may need to enable JavaScript!
  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
There should be some charts here, you may need to enable JavaScript!
  • Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
There should be some charts here, you may need to enable JavaScript!
  • Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform in Human [ChEMBL: CHEMBL4703] [UniProtKB: P67775]
There should be some charts here, you may need to enable JavaScript!
  • Serine-threonine protein phosphatase 2A regulatory subunit in Chicken [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
There should be some charts here, you may need to enable JavaScript!
  • Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Protein phosphatase 2C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2845] [UniProtKB: O75688]
ChEMBL Inhibitory concentration against Protein phosphatase 1(10 nM) isolated from rabbit muscle B 6.9 pIC50 126 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 647-649 [PMID:11266161]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition activity against protein phosphatase 1 (PP1), activity taken from literature B 5.89 pIC50 1300 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL Inhibitory concentration against Protein phosphatase 1 was determined B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 391-393 [PMID:11814804]
ChEMBL Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle B 8.47 pIC50 3.4 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1029-1034
ChEMBL Observed inhibition activity against protein phosphatase 1 (PP1) B 8.91 pIC50 1.24 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
ChEMBL Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes B 10.15 pIC50 0.07 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1029-1034
Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4703] [UniProtKB: P67775]
ChEMBL Inhibitory concentration against Protein phosphatase 2A (25 nM) isolated from bovine myocardial tissue B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 647-649 [PMID:11266161]
Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
ChEMBL Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature B 9 pIC50 1 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL Concentration required to inhibit the action of protein phosphatase 2A B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 391-393 [PMID:11814804]
ChEMBL Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) B 9 pIC50 1 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Observed inhibition activity against protein phosphatase 2A (PP2A) B 9.35 pIC50 0.45 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R221S by compound was evalutade B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type N124D by compound was evalutade B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type H248N by compound was evalutade B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D208A by compound was evalutade B 5.3 pIC50 >5000 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type Y272F by compound was evalutade B 5.94 pIC50 1150 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R96A by compound was evalutade B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type C127S by compound was evalutade B 7.11 pIC50 78 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E275R by compound was evalutade B 7.32 pIC50 48 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type B 7.35 pIC50 45 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D220V by compound was evalutade B 7.55 pIC50 28 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibitory activity against serine/threonine protein phosphatase 1(PP1) B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2004) 47: 10-13 [PMID:14695814]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]