okadaic acid [Ligand Id: 5349] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL280487 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Protein phosphatase 2C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2845] [UniProtKB: O75688] | ||||||||
| ChEMBL | Inhibitory concentration against Protein phosphatase 1(10 nM) isolated from rabbit muscle | B | 6.9 | pIC50 | 126 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 647-649 [PMID:11266161] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition activity against protein phosphatase 1 (PP1), activity taken from literature | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| ChEMBL | Inhibitory concentration against Protein phosphatase 1 was determined | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804] |
| ChEMBL | Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| ChEMBL | Observed inhibition activity against protein phosphatase 1 (PP1) | B | 8.91 | pIC50 | 1.24 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172] | ||||||||
| ChEMBL | Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes | B | 10.15 | pIC50 | 0.07 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| protein phosphatase 2 catalytic subunit alpha/Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4703] [GtoPdb: 3263] [UniProtKB: P67775] | ||||||||
| ChEMBL | Inhibitory concentration against Protein phosphatase 2A (25 nM) isolated from bovine myocardial tissue | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 647-649 [PMID:11266161] |
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804] |
| Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3] | ||||||||
| ChEMBL | Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| ChEMBL | Concentration required to inhibit the action of protein phosphatase 2A | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804] |
| ChEMBL | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Observed inhibition activity against protein phosphatase 2A (PP2A) | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873] | ||||||||
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R221S by compound was evaluated | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type N124D by compound was evaluated | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type H248N by compound was evaluated | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D208A by compound was evaluated | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type Y272F by compound was evaluated | B | 5.94 | pIC50 | 1150 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R96A by compound was evaluated | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type C127S by compound was evaluated | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E275R by compound was evaluated | B | 7.32 | pIC50 | 48 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D220V by compound was evaluated | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibitory activity against serine/threonine protein phosphatase 1(PP1) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2004) 47: 10-13 [PMID:14695814] |
| protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136] | ||||||||
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
