okadaic acid [Ligand Id: 5349] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL280487 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Protein phosphatase 2C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2845] [UniProtKB: O75688] | ||||||||
| ChEMBL | Inhibitory concentration against Protein phosphatase 1(10 nM) isolated from rabbit muscle | B | 6.9 | pIC50 | 126 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 647-649 [PMID:11266161] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition activity against protein phosphatase 1 (PP1), activity taken from literature | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| ChEMBL | Inhibitory concentration against Protein phosphatase 1 was determined | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804] |
| ChEMBL | Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| ChEMBL | Observed inhibition activity against protein phosphatase 1 (PP1) | B | 8.91 | pIC50 | 1.24 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172] | ||||||||
| ChEMBL | Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes | B | 10.15 | pIC50 | 0.07 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| protein phosphatase 2 catalytic subunit alpha/Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4703] [GtoPdb: 3263] [UniProtKB: P67775] | ||||||||
| ChEMBL | Inhibitory concentration against Protein phosphatase 2A (25 nM) isolated from bovine myocardial tissue | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 647-649 [PMID:11266161] |
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804] |
| Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3] | ||||||||
| ChEMBL | Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literature | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| ChEMBL | Concentration required to inhibit the action of protein phosphatase 2A | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804] |
| ChEMBL | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Observed inhibition activity against protein phosphatase 2A (PP2A) | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873] | ||||||||
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R221S by compound was evalutade | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type N124D by compound was evalutade | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type H248N by compound was evalutade | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D208A by compound was evalutade | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type Y272F by compound was evalutade | B | 5.94 | pIC50 | 1150 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type R96A by compound was evalutade | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type C127S by compound was evalutade | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E275R by compound was evalutade | B | 7.32 | pIC50 | 48 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type D220V by compound was evalutade | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibitory activity against serine/threonine protein phosphatase 1(PP1) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2004) 47: 10-13 [PMID:14695814] |
| protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136] | ||||||||
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
