saccharin [Ligand Id: 5432] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL310671 (Gluside, Benzosulfinide, INS-954(I), INS NO.954(I), NSC-5349, Sweeta, E954, Saccharin, E-954(I))
  • AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
  • This target only has 1 pki data point
  • 7.02
1 CHEMBL310671_lig_chart_1 AGAP002992-PA Anopheles gambiae
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  • Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
  • 7.39
2 CHEMBL310671_lig_chart_2 Alpha carbonic anhydrase Stylophora pistillata
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  • Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
  • This target only has 1 pki data point
  • 6.12
3 CHEMBL310671_lig_chart_3 Astrosclerin-3 Astrosclera willeyana
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • This target only has 0 pki data point
  • 0
4 CHEMBL310671_lig_chart_4 Butyrylcholinesterase Human
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  • Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
  • This target only has 1 pki data point
  • 6.06
5 CHEMBL310671_lig_chart_5 Carbonate dehydratase Sulfurihydrogenibium sp. (strain YO3AOP1)
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  • Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
  • Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
  • Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
  • Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
  • 4.9
6 CHEMBL310671_lig_chart_6 Carbonic anhydrase Mycobacterium tuberculosisStylophora pistillataCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Saccharomyces cerevisiae S288c
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  • Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
  • This target only has 1 pki data point
  • 6.03
7 CHEMBL310671_lig_chart_7 Carbonic anhydrase, alpha family Thiomicrospira crunogena (strain XCL-2)
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
  • 4.73
8 CHEMBL310671_lig_chart_8 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
  • 5.23
9 CHEMBL310671_lig_chart_9 Carbonic anhydrase II Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • This target only has 1 pki data point
  • 5.1
10 CHEMBL310671_lig_chart_10 Carbonic anhydrase IV Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
  • 6.99
11 CHEMBL310671_lig_chart_11 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
  • This target only has 1 pki data point
  • 5
12 CHEMBL310671_lig_chart_12 Carbonic anhydrase VA Human
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  • Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
  • This target only has 1 pki data point
  • 5.14
13 CHEMBL310671_lig_chart_13 Carbonic anhydrase VB Human
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14 CHEMBL310671_lig_chart_14 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • 8
15 CHEMBL310671_lig_chart_15 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
  • 6.2
16 CHEMBL310671_lig_chart_16 Carbonic anhydrase XII Human
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
  • This target only has 1 pki data point
  • 6.11
17 CHEMBL310671_lig_chart_17 Carbonic anhydrase XIV Human
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  • Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
  • This target only has 1 pki data point
  • 5.04
18 CHEMBL310671_lig_chart_18 Delta carbonic anhydrase Thalassiosira weissflogii
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  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
  • This target only has 1 pki data point
  • 5.1
19 CHEMBL310671_lig_chart_19 Uncharacterized protein Rv1284/MT1322 Mycobacterium tuberculosis
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.02 pKi 95.3 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay B 7.39 pKi 40.3 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay B 7.39 pKi 40.3 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 6.12 pKi 751 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of BuChE (unknown origin) assessed as reduction in S-butyrylthiocholine chloride hydrolysis after 15 mins by Ellman method B 5.44 pIC50 3600 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 626-630 [PMID:25537270]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay B 6.06 pKi 876 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay B 6.1 pKi 792 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 6.98 pKi 104 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay B 6.13 pKi 736 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay B 4.9 pKi 12500 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay B 6.03 pKi 933 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay B 4.7 pKi >20000 nM Ki J Med Chem (2018) 61: 1176-1181 [PMID:29266943]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method B 4.73 pKi 18540 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki J. Med. Chem. (2012) 55: 10742-10748 [PMID:23181552]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human esterase activity of carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2013) 21: 1522-1525 [PMID:22974493]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
ChEMBL Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis B 4.73 pKi 18540 nM Ki Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay B 4.73 pKi 18540 nM Ki Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
ChEMBL Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay B 4.73 pKi 18540 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 836-841 [PMID:18042384]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.73 pKi 18540 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 5.13 pKi 7470 nM Ki Bioorg. Med. Chem. (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay B 5.22 pKi 6000 nM Ki J Med Chem (2018) 61: 1176-1181 [PMID:29266943]
ChEMBL Binding affinity to carbonic anhydrase 2 (unknown origin) B 5.22 pKi 6000 nM Ki ACS Med Chem Lett (2018) 9: 657-661 [PMID:30034596]
ChEMBL Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
ChEMBL Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 5.22 pKi 5959 nM Ki J. Med. Chem. (2012) 55: 10742-10748 [PMID:23181552]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis B 5.22 pKi 5959 nM Ki Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay B 5.22 pKi 5959 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. Lett. (2014) 24: 275-279 [PMID:24314394]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibition of human wild type carbonic anhydrase 2 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay B 5.22 pKi 5959 nM Ki Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method B 5.23 pKi 5950 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human esterase activity of carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2013) 21: 1522-1525 [PMID:22974493]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
ChEMBL Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay B 5.23 pKi 5950 nM Ki Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay B 5.23 pKi 5950 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 836-841 [PMID:18042384]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay B 5.23 pKi 5950 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
ChEMBL Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 5.29 pKi 5180 nM Ki Bioorg. Med. Chem. (2012) 20: 2208-2213 [PMID:22386980]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli by stopped flow CO2 hydration assay B 5.1 pKi 7920 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 catalytic site preincubated for 15 mins by stopped flow CO2 hydration assay B 6.99 pKi 103 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
ChEMBL Inhibition of human esterase activity of carbonic anhydrase 9 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis B 6.99 pKi 103 nM Ki Bioorg. Med. Chem. (2013) 21: 1522-1525 [PMID:22974493]
ChEMBL Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay B 6.99 pKi 103 nM Ki Bioorg. Med. Chem. (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay B 6.99 pKi 103 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
ChEMBL Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay B 6.99 pKi 103 nM Ki Bioorg. Med. Chem. (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay B 6.99 pKi 103 nM Ki Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL Inhibition of human carbonic anhydrase 9 catalytic site preincubated for 15 mins by stopped flow CO2 hydration assay B 6.99 pKi 103 nM Ki J Med Chem (2016) 59: 6547-6552 [PMID:27305384]
ChEMBL Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay B 6.99 pKi 103 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 836-841 [PMID:18042384]
ChEMBL Inhibition of recombinant human carbonic anhydrase 9 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 6.99 pKi 103 nM Ki J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL Inhibition of recombinant human carbonic anhydrase 9 expressed in Escherichia coli L21-GOLD (DE3) incubated for 10 mins prior to testing by stopped-flow CO2 hydration assay B 7 pKi 100 nM Ki J Med Chem (2018) 61: 1176-1181 [PMID:29266943]
ChEMBL Binding affinity to carbonic anhydrase 9 (unknown origin) expressed in Escherichia coli BL21 (DE3) B 7 pKi 100 nM Ki ACS Med Chem Lett (2018) 9: 657-661 [PMID:30034596]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Inhibition of human recombinant carbonic anhydrase 5A expressed in Escherichia coli by stopped flow CO2 hydration assay B 5 pKi 10060 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Inhibition of human recombinant carbonic anhydrase 5B expressed in Escherichia coli by stopped flow CO2 hydration assay B 5.14 pKi 7210 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay B 6.03 pKi 935 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human recombinant carbonic anhydrase 6 expressed in Escherichia coli by stopped flow CO2 hydration assay B 6.03 pKi 935 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli by stopped flow CO2 hydration assay B 8 pKi 10 nM Ki J. Med. Chem. (2014) 57: 3522-3531 [PMID:24689792]
ChEMBL Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay B 8