gabapentin [Ligand Id: 5483] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL940 (CI-945, DM-1796, Gabapentin, GOE 3450, GOE-3450, Gralise, Neurontin, NSC-742194, NSC-759254)
  • Voltage-dependent calcium channel alpha2delta subunit in Pig [ChEMBL: CHEMBL3985] [UniProtKB: O77773]
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  • Voltage-gated calcium channel alpha2/delta subunit 1 in Human [ChEMBL: CHEMBL1919] [UniProtKB: P54289]
  • Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse [ChEMBL: CHEMBL4676] [UniProtKB: O08532]
  • Voltage-gated calcium channel alpha2/delta subunit 1 in Rat [ChEMBL: CHEMBL3420] [UniProtKB: P54290]
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  • Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525]
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  • Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Voltage-dependent calcium channel alpha2delta subunit in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3985] [UniProtKB: O77773]
ChEMBL Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins B 6.85 pIC50 140 nM IC50 Bioorg Med Chem Lett (2010) 20: 362-365 [PMID:19897364]
ChEMBL Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane B 7.15 pIC50 70 nM IC50 Bioorg Med Chem Lett (2006) 16: 2333-2336 [PMID:15946842]
Voltage-gated calcium channel alpha2/delta subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1919] [UniProtKB: P54289]
ChEMBL Binding affinity towards alpha2-delta subunit of a voltage gated calcium channel using [3H]gabapentin in human brain membrane (A710 membrane) B 7.57 pIC50 27 nM IC50 Bioorg Med Chem Lett (2004) 14: 1913-1916 [PMID:15050626]
Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4676] [UniProtKB: O08532]
ChEMBL Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain B 6.92 pKi 120.23 nM Ki Bioorg Med Chem Lett (2006) 16: 1138-1141 [PMID:16380257]
ChEMBL Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain B 6.92 pKi 120 nM Ki Bioorg Med Chem Lett (2006) 16: 1138-1141 [PMID:16380257]
Voltage-gated calcium channel alpha2/delta subunit 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3420] [UniProtKB: P54290]
ChEMBL Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortex F 5.05 pIC50 8900 nM IC50 Bioorg Med Chem Lett (2006) 16: 2333-2336 [PMID:15946842]
Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525]
GtoPdb - - 8.28 pEC50 5.3 nM EC50 Mol Pharmacol (2018) 94: 1155-1163 [PMID:30021858]
Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82]
GtoPdb - - 8.72 pEC50 1.9 nM EC50 Mol Pharmacol (2018) 94: 1155-1163 [PMID:30021858]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]