gallic acid [Ligand Id: 5549] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL288114 (Benzoic acid, 3,4,5-trihydroxy-, Gallate, Gallic acid, NSC-20103, NSC-674319)
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  • Alpha-glucosidase MAL62 in Saccharomyces cerevisiae [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
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  • Autoinducer 2-binding periplasmic protein luxP in Vibrio harveyi [ChEMBL: CHEMBL6100] [UniProtKB: P54300]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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  • Leukocyte adhesion molecule-1 in Human [ChEMBL: CHEMBL3161] [UniProtKB: P14151]
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  • Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
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  • Polypeptide N-acetylgalactosaminyltransferase 2 in Human [ChEMBL: CHEMBL3713355] [UniProtKB: Q10471]
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  • squalene monooxygenase/Squalene monooxygenase in Rat [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-(1,3)-fucosyltransferase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596077] [UniProtKB: Q11130]
ChEMBL Inhibition of FucT-7 (unknown origin) B 7.22 pIC50 60 nM IC50 MedChemComm (2014) 5: 1106-1125
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
ChEMBL Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry B 0.72 pIC50 0.72 - logIC50 Med Chem Res (2012) 21: 3984-3993
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assay B 5.35 pIC50 4430 nM IC50 Bioorg Med Chem (2020) 28: 115596-115596 [PMID:32631566]
Autoinducer 2-binding periplasmic protein luxP in Vibrio harveyi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6100] [UniProtKB: P54300]
ChEMBL Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer-2-mediated quorum sensing after 3 to 4 hrs F 4.3 pIC50 50000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1567-1572 [PMID:18262415]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay B 5.38 pKi 4130 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 4259-4262 [PMID:21669522]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human CA1 by stopped-flow CO2 hydration assay B 5.49 pKi 3200 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
GtoPdb - - 5.5 pKi 3200 nM Ki Bioorg Med Chem (2010) 18: 2159-64 [PMID:20185318]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human CA2 by stopped-flow CO2 hydration assay B 5.65 pKi 2250 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL Inhibition of human CA3 by stopped-flow CO2 hydration assay B 5.13 pKi 7490 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human CA4 by stopped-flow CO2 hydration assay B 5.01 pKi 9800 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human CA9 by stopped-flow CO2 hydration assay B 5.16 pKi 6990 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Inhibition of human CA5A by stopped-flow CO2 hydration assay B 5.39 pKi 4080 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Inhibition of human CA5B by stopped-flow CO2 hydration assay B 5 pKi 9970 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human CA6 by stopped-flow CO2 hydration assay B 5.21 pKi 6130 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human CA7 by stopped-flow CO2 hydration assay B 5.22 pKi 6070 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human CA12 by stopped-flow CO2 hydration assay B 5.11 pKi 7780 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse CA13 by stopped-flow CO2 hydration assay B 5.01 pKi 9860 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human CA14 by stopped-flow CO2 hydration assay B 5.15 pKi 7030 nM Ki Bioorg. Med. Chem. (2010) 18: 2159-2164 [PMID:20185318]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay B 5.33 pIC50 4650 nM IC50 Eur J Med Chem (2018) 151: 145-157 [PMID:29609120]
Fucosyltransferase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4996] [UniProtKB: P22083]
ChEMBL Inhibition of FucT-4 (unknown origin) B 4.85 pIC50 14000 nM IC50 MedChemComm (2014) 5: 1106-1125
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2763-2767 [PMID:11591519]
Leukocyte adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3161] [UniProtKB: P14151]
ChEMBL Inhibition of human L-selectin after 2 hrs B 4.56 pIC50 27600 nM IC50 J. Med. Chem. (2007) 50: 1101-1115 [PMID:17302397]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2008) 16: 9867-9870 [PMID:18926710]
Polypeptide N-acetylgalactosaminyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3713355] [UniProtKB: Q10471]
ChEMBL Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation constant by SPR analysis B 6.03 pKd 924 nM Kd Bioorg Med Chem (2019) 27: 3372-3382 [PMID:31227364]
ChEMBL Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293T cells and using 5-FAM labelled-EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay B 5.86 pIC50 1370 nM IC50 Bioorg Med Chem (2019) 27: 3372-3382 [PMID:31227364]
selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109]
ChEMBL Inhibition of human P-selectin after 2 hrs B 4.72 pIC50 19100 nM IC50 J. Med. Chem. (2007) 50: 1101-1115 [PMID:17302397]
squalene monooxygenase/Squalene monooxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020]
ChEMBL Inhibition of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia coli B 4.14 pIC50 73000 nM IC50 J. Nat. Prod. (2001) 64: 1010-1014 [PMID:11520216]
TLR2/Toll-like receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075106] [GtoPdb: 1752] [UniProtKB: Q9QUN7]
ChEMBL Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production measured after 24 hrs by Griess assay B 4.16 pIC50 69250 nM IC50 Eur J Med Chem (2019) 179: 233-245 [PMID:31255924]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]