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ChEMBL ligand: CHEMBL32800 (Airum, Berodual, Berodual n, Berotec, Berotec 100, Berotec 200, Berotec [as hydrobromide], Dosberotec, Duovent, Fenoterol, Fenoterol hbr, Fenoterol hydrobromide, NSC-757811, Partusisten, TH-1165, TH 1165A, TH-1165A, TH 1165A [AS HYDROBROMIDE SALT], TH 1165A FREE BASE, TH-1165A FREE BASE) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
ChEMBL | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis | B | 6.86 | pKd | 139 | nM | Kd | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
ChEMBL | Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem Lett (2013) 23: 5376-5381 [PMID:23954364] |
ChEMBL | Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in HEK293 cells after 1 hr by scintillation counting analysis | B | 6.9 | pKi | 126 | nM | Ki | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
GtoPdb | - | - | 7 | pKi | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993]; Br J Pharmacol (2022) 179: 4692-4708 [PMID:35732075]; Mol Pharmacol (2015) 87: 103-20 [PMID:25324048] |
GtoPdb | - | - | 8.9 | pEC50 | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; Br J Pharmacol (2022) 179: 4692-4708 [PMID:35732075] |
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
ChEMBL | In vitro inhibitory concentration Beta-2 adrenergic receptor in Guinea pig trachea | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2687-2692 [PMID:12873495] |
ChEMBL | Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction in presence of 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one | F | 7.72 | pEC50 | 19 | nM | EC50 | J Med Chem (2007) 50: 5003-5011 [PMID:17845020] |
ChEMBL | Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction | F | 7.74 | pEC50 | 18 | nM | EC50 | J Med Chem (2007) 50: 5003-5011 [PMID:17845020] |
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | - | - | 5 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
GtoPdb | - | - | 7.5 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
GtoPdb | - | - | 5.4 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
GtoPdb | - | - | 7.6 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]