fenoterol [Ligand Id: 557] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL32800 (Berotec 100, TH 1165A FREE BASE, Duovent, TH 1165A [AS HYDROBROMIDE SALT], Fenoterol hydrobromide, Berotec 200, TH-1165A FREE BASE, Fenoterol, Berodual, Berodual n, TH-1165, Berotec, Berotec [as hydrobromide])
  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
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1 CHEMBL32800_lig_chart_1 Beta-2 adrenergic receptor HumanGuinea pig
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis B 6.86 pKd 139 nM Kd ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
ChEMBL Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM B 7 pKd 100 nM Kd Bioorg. Med. Chem. Lett. (2013) 23: 5376-5381 [PMID:23954364]
ChEMBL Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in HEK293 cells after 1 hr by scintillation counting analysis B 6.9 pKi 126 nM Ki ACS Med. Chem. Lett. (2013) 4: 1005-1010 [PMID:24454993]
GtoPdb - - 6.9 pKi 126 nM Ki ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL In vitro inhibitory concentration Beta-2 adrenergic receptor in Guinea pig trachea B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2687-2692 [PMID:12873495]
ChEMBL Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction in presence of 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one F 7.72 pEC50 19 nM EC50 J. Med. Chem. (2007) 50: 5003-5011 [PMID:17845020]
ChEMBL Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction F 7.74 pEC50 18 nM EC50 J. Med. Chem. (2007) 50: 5003-5011 [PMID:17845020]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]